Khellin: A furanochromone with toxicity against Oncopeltus fasciatus (Hemiptera) and Aedes aegypti (Diptera)

Universidade Severino Sombra (USS). Laboratório de Insetos Vetores/CECETEN. Vassouras, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Díptera. Rio de Janeiro, RJ, Brasil / Universidade do Porto. Centro de Química Medicina - CEQUIMED-UP. Porto, Portugal.
Universidade Severino Sombra (USS). Laboratório de Insetos Vetores/CECETEN. Vassouras, RJ, Brasil.
Universidade Severino Sombra (USS). Laboratório de Insetos Vetores/CECETEN. Vassouras, RJ, Brasil / Universidade Severino Sombra (USS). Mestrado Profissional em Ciências Ambientais. Vassouras, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Díptera. Rio de Janeiro, RJ, Brasil.
Universidade Severino Sombra (USS). Laboratório de Insetos Vetores/CECETEN. Vassouras, RJ, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Díptera. Rio de Janeiro, RJ, Brasil.
Istanbul Üniversity. Science Faculty. Molecular Biyoloji and Genetics. Turkey.
Universidade do Porto. Faculdade de Farmácia. Departamento de Ciências Químicas. Laboratório de Química Orgânica e Farmacêutica. Porto, Portugal / Universidade do Porto. Centro de Química Medicina - CEQUIMED-UP. Porto, Portugal / Universidade Severino Sombra (USS). Mestrado Profissional em Ciências Ambientais. Vassouras, RJ, Brasil.

Abstract

Natural products isolated from plants may be an alternative source of larvicidal and insecticide activity. Khellin is a natural furanochromone isolated from fruits of Ammi visnaga (L.) Lam. (Umbelliferae family), which grows extensively in the Mediterranean region. This substance shows several types of biological activity, such as in vitro cytotoxicity, antispasmodic action, and phototherapeutic potential. Dengue is a tropical disease caused by an arbovirus transmitted by Aedes aegypti; the milkweed bug, Oncopeltus fasciatus, is a phytophagous Hemiptera and a Phytomonas vector. Our main goal was to evaluate the toxicity of khellin in relation to the nymphs of O. fasciatus (Hemiptera) and larvae of A. aegypti (Diptera). To the best of our knowledge, this is the fi rst report concerning furanochromone bioactivity against insect vectors for human disease.

Publisher

Pharmacognosy Network Worldwide

Citation

MALEK, Marise; et al. Khellin: A furanochromone with toxicity against Oncopeltus fasciatus (Hemiptera) and Aedes aegypti (Diptera). Journal of Natural Pharmaceuticals, v.4, n.1, p.32-36, Jan. / June 2013.

DOI

10.4103/2229-5119.110348

ISSN

2229-5119

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12516

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Pharmacognosy Network Worldwide

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