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STRUCTURAL AND FUNCTIONAL MICROVASCULAR ALTERATIONS IN A RAT MODEL OF METABOLIC SYNDROME INDUCED BY A HIGH-FAT DIET
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Investigação Cardiovascular. Rio de Janeiro, RJ, Brasil.
Abstract
Objective: To investigate microvascular alterations in an experimental model of metabolic syndrome
induced by a high-fat diet (HFD) associated with salt supplementation (0.5% NaCl).
Design and Methods: Wistar Kyoto rats were fed standard chow (control group, CONT) or HFD for
20 weeks. The functional capillary density (FCD) was assessed using intravital fluorescence
videomicroscopy.
Results: The HFD group presented a higher systolic blood pressure, plasma glucose and insulin levels,
total and LDL-cholesterol levels, triglycerides, and visceral and epididymal fat when compared with the
CONT group. When compared with the CONT group, the HFD group showed a lower FCD in the skeletal
muscle (P < 0.05) but not in the skin (P > 0.05). The HFD group also had a lower capillary-to-fiber ratio
in the skeletal muscle (P < 0.01). The capillary volume density-to-fiber volume density ratio in the left
ventricle of the HFD was also reduced (P < 0.01). Finally, rats fed with HFD showed ventricular
hypertrophy and increased cardiomyocyte diameter (P < 0.01).
Conclusions: The long-term administration of a HFD associated with salt supplementation to rats
generates an experimental model of metabolic syndrome characterized by central body fat deposition,
insulin resistance, glucose intolerance, hypertriglyceridemia, hypercholesterolemia, arterial hypertension,
cardiac remodeling, and rarefaction of the microcirculation in the heart and skeletal muscle.
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