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https://www.arca.fiocruz.br/handle/icict/12747
BIPOLAR DISORDER PREVALENCE: A SYSTEMATIC REVIEW AND META-ANALYSIS OF THE LITERATURE
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental.Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia de Medicina Molecular. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental.Belo Horizonte, MG, Brasil.
Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Instituto Nacional de Ciência e Tecnologia de Medicina Translacional. Laboratório de Psiquiatria Molecular. Porto Alegre, RS, Brasil / University of Texas Health Science Center. Department of Psychiatry and Behavioral Sciences. Center of Excellence on Mood Disorders. Houston, TX, USA.
University of Texas Health Science Center. Department of Psychiatry and Behavioral Sciences. Center of Excellence on Mood Disorders. Houston, TX, USA.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental.Belo Horizonte, MG, Brasil / Universidade Federal de Minas Gerais. Instituto Nacional de Ciência e Tecnologia de Medicina Molecular. Belo Horizonte, MG, Brasil.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Departamento de Saúde Mental.Belo Horizonte, MG, Brasil.
Universidade Federal do Rio Grande do Sul. Hospital de Clínicas de Porto Alegre. Instituto Nacional de Ciência e Tecnologia de Medicina Translacional. Laboratório de Psiquiatria Molecular. Porto Alegre, RS, Brasil / University of Texas Health Science Center. Department of Psychiatry and Behavioral Sciences. Center of Excellence on Mood Disorders. Houston, TX, USA.
University of Texas Health Science Center. Department of Psychiatry and Behavioral Sciences. Center of Excellence on Mood Disorders. Houston, TX, USA.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas René Rachou. Belo Horizonte, MG, Brasil.
Abstract
Objective: Bipolar disorder (BD) is common in clinical psychiatric practice, and several studies have estimated its prevalence to range from 0.5 to 5% in community-based samples. However, no systematic review and meta-analysis of the prevalence of BD type 1 and type 2 has been published in the literature. We carried out a systematic review and meta-analysis of the lifetime and 1-year prevalence of BD type 1 and type 2 and assessed whether the prevalence of BD changed according to the diagnostic criteria adopted (DSM-III, DSM-III-R vs. DSM-IV).
Methods: We searched MEDLINE, Scopus, Web of Science, PsycINFO, and the reference lists of identified studies. The analyses included 25 population- or community-based studies and 276,221 participants.
Results: The pooled lifetime prevalence of BD type 1 was 1.06% (95% confidence interval [95%CI] 0.81-1.31) and that of BD type 2 was 1.57% (95%CI 1.15-1.99). The pooled 1-year prevalence was 0.71% (95%CI 0.56-0.86) for BD type 1 and 0.50% (95%CI 0.35-0.64) for BD type 2. Subgroup analysis showed a significantly higher lifetime prevalence of BD type 1 according to the DSM-IV criteria compared to the DSM-III and DSM-IIIR criteria (p < 0.001).
Conclusion: This meta-analysis confirms that estimates of BD type 1 and type 2 prevalence are low in the general population. The increase in prevalence from DSM-III and DSM-III-R to DSM-IV may reflect different factors, such as minor changes in diagnostic operationalization, use of different assessment instruments, or even a genuine increase in the prevalence of BD.
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