A tale from TGF-β superfamily for thymus ontogeny and function

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.

Abstract

Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/bone morphogenetic protein ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.

Keywords

TGF-β
BMP
Thymus
Thymopoiesis
T cell development

DeCS

Timo

Publisher

Frontiers Media

Citation

JURBERG, Arnon Dias; FONTES, Larissa Vasconcelos; ALMEIDA, Vinícius Cotta de. A tale from TGF-β superfamily for thymus ontogeny and function. Frontiers in Immunology, v.6, Article 442, 15p, Aug. 2015.

DOI

10.3389/fimmu.2015.00442

ISSN

1664-3224

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12771

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Open access

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