Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/12771
Title: A tale from TGF-β superfamily for thymus ontogeny and function
Authors: Jurberg, Arnon Dias
Fontes, Larissa Vasconcelos
Almeida, Vinícius Cotta de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil / Universidade Federal do Rio de Janeiro. Instituto de Ciências Biomédicas. Programa de Pós-Graduação em Biologia Celular e do Desenvolvimento. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Pesquisa sobre o Timo. Rio de Janeiro, RJ, Brasil.
Abstract: Multiple signaling pathways control every aspect of cell behavior, organ formation, and tissue homeostasis throughout the lifespan of any individual. This review takes an ontogenetic view focused on the large superfamily of TGF-β/bone morphogenetic protein ligands to address thymus morphogenesis and function in T cell differentiation. Recent findings on a role of GDF11 for reversing aging-related phenotypes are also discussed.
Keywords: TGF-β
BMP
Thymus
Thymopoiesis
T cell development
DeCS: Timo
Issue Date: 2015
Publisher: Frontiers Media
Citation: JURBERG, Arnon Dias; FONTES, Larissa Vasconcelos; ALMEIDA, Vinícius Cotta de. A tale from TGF-β superfamily for thymus ontogeny and function. Frontiers in Immunology, v.6, Article 442, 15p, Aug. 2015.
DOI: 10.3389/fimmu.2015.00442
ISSN: 1664-3224
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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