Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/13428
Title: Studies on anti-componenet 5 antibodies in animals infected with Trypanosoma cruzi
Authors: Santoro, Ferrucio
Sadigursky, Moysés
Sherlock, Ítalo Rodrigues de Araújo
Afchain, Daniel
Capron, A.
Affilliation: Institut Pasteur. Centre d’Immunologie et de Biologie Parasitaire. (Unité Mixte INSERM). Lille Cédex, France
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Institut Pasteur. Centre d’Immunologie et de Biologie Parasitaire. (Unité Mixte INSERM). Lille Cédex, France
Institut Pasteur. Centre d’Immunologie et de Biologie Parasitaire. (Unité Mixte INSERM). Lille Cédex, France
Abstract: A competitive antibody enzyme immunoassay, using a monoclonal antibody against the species-specific Trypanosoma cruzi antigen 5, was used to investigate the presence o f anti-component 5 antibodies in sera of opossums, dogs, rabbits and rats infected with this parasite. The sera from 51 Venezuelan patients with Chagas’disease were also tested. About 90% of the infected subjects showed significant levels o f anti-component 5 antibodies. Nevertheless, these antibodies were not detected in the sera o f dogs, rats and opossums infected with T. cruzi. Some sera from infected rabbits presented significant results but close to the limit o f positivity o f the test. Thesefindings suggest that the immune response in animals naturally or experimentally infected with T. cruzi is different from that observed in human Chagas’disease.
Keywords: Trypanosoma cruzi
Antibodies
Immunoassay
Issue Date: 1987
Publisher: Sociedade Brasileira de Medicina Tropical
Citation: SANTORO, F. et al. Studies on anti-componenet 5 antibodies in animals infected with Trypanosoma cruzi. Revista da Sociedade Brasileira de Medicina Tropical, v. 20, n. 2, p. 91-94, 1987.
ISSN: 0037-8682
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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