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CO-INFECTIONS FROM ZIKA AND CHIKUNGUNYA VIRUS IN BAHIA, BRAZIL IDENTIFIED BY METAGENOMIC NEXT-GENERATION SEQUENCING
Sardi, Silvia et al. | Date Issued: 2016
Author
Sardi, Silvia
Somasekar, Sneha
Naccache, Samia N.
Bandeira, Antonio Carlos de Albuquerque
Tauro, Laura Beatriz
Campos, Gubio Soares
Chiu, Charles Y.
Affilliation
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Virologia. Salvador, BA, Brasil.
University of California. Department of Laboratory Medicine. San Francisco, CA / UCSF. Abbott Viral Diagnostics and Discovery Center. San Francisco, CA, USA.
University of California. Department of Laboratory Medicine. San Francisco, CA / UCSF. Abbott Viral Diagnostics and Discovery Center. San Francisco, CA, USA.
Hospital Aliança. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Universidade Federal da Bahia. Instituto de Ciências da Saúde. Laboratório de Virologia. Salvador, BA, Brasil.
University of California. Department of Laboratory Medicine. San Francisco, CA, USA / UCSF. Abbott Viral Diagnostics and Discovery Center. San Francisco, CA, USA / University of California. Department of Medicine. Division of Infectious Diseases. San Francisco, CA, USA.
Abstract
Metagenomic next-generation sequencing (mNGS) of 15 patients with documented ZIKV infection in Bahia, Brazil from April 2015 to January 2016 identified co-infections with chikungunya virus (CHIKV) in 2 of 15 ZIKV PCR-positive cases (13.3%). While generally non-specific, the clinical presentation corresponding to these two CHIKV/ZIKV co-infections reflected infection by the virus present at higher titer. Aside from CHIKV and ZIKV, co-infections from other viral pathogens were not detected. The mNGS approach is promsiing for differential diagnosis of acute febrile illness and identification of co-infections, although targeted arbovirus screening may be sufficient in the current ZIKV outbreak setting.
Keywords
Chikungunya virus
Zika Virus
Virus Infections
Arboviruses
PCR
Coinfection
Humans
Diagnosis, Differential
Brazil
 
Publisher
American Society for Microbiology
Citation
SARDI, S. et al. Co-Infections from Zika and Chikungunya Virus in Bahia, Brazil Identified by Metagenomic Next-Generation Sequencing. Journal of Clinical Microbiology, p. 1-19, Jul. 2016.
DOI
10.1128/JCM.00877-16
ISSN
0095-1137