| Author | Almeida, Antonio Eugenio Castro Cardoso de | |
| Author | Filippis, Ivano de | |
| Author | Abreu, Alessandra Oliveira de | |
| Author | Ferreira, Diana Guedes | |
| Author | Gemal, André Luis | |
| Author | Marzochi, Keyla Belizia Feldman | |
| Access date | 2016-08-16T17:07:47Z | |
| Available date | 2016-08-16T17:07:47Z | |
| Document date | 2005 | |
| Citation | ALMEIDA, A. E. C. C. et al. Occurrence of Haemophilus influenzae strains in three Brazilian states since the introduction of a conjugate Haemophilus influenzae type b vaccine. Brazilian Journal of Medical and Biological Research, Ribeirão Preto, v. 38, n. 5, p. 777-781, maio 2005. | pt_BR |
| ISSN | 1414-431X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15273 | |
| Language | eng | pt_BR |
| Publisher | Associação Brasileira de Divulgação Científica | pt_BR |
| Rights | open access | pt_BR |
| Title | Occurrence of Haemophilus influenzae strains in three Brazilian states since the introduction of a conjugate Haemophilus influenzae type b vaccine | en |
| Type | Article | pt_BR |
| DOI | 10.1590/S0100-879X2005000500016 | pt_BR |
| Abstract | Few vaccines in history have induced such a dramatic decline in incidence over such a short period of time as the Haemophilus influenzae type b (Hib) conjugate. This vaccine was introduced in 1988 in the United States, but only in 1999 was Hib immunization introduced by the Brazilian Ministry of Health as part of the routine infant National Immunization Program. The authors analyzed 229 H. influenzae (Hi) isolates from Public Health Laboratories in three Brazilian states: Pernambuco (Northeast, N = 54), Santa Catarina (South, N = 19), and Rio de Janeiro (Southeast, N = 156). The isolates were collected from Brazilian children 0-10 years of age with meningitis and other infections from 1990 to 2003 and were part of the research collection of the National Institute of Quality Control in Health, FIOCRUZ. Bacterial strains were characterized by serotyping and biotyping. During the pre-vaccination period the prevalence infection due to Hib was of 165 isolates and only 2 non-b Hi among all the notified meningitis infections caused by Hi. Our results showed a significant decrease in the prevalence of Hib meningitis from 165 to 33 isolates after 1999. However, during the post-vaccination period of 2001-2003 we observed an increase in the number of non-b Hi isolates: only 2 non-b strains isolated from 1990 to 1999 and 29 from 1999 to 2003. Based on the present data, the authors emphasize the need for more sensitive epidemiological and bacteriological studies aiming the improvement of the available Hib vaccine, in order to protect the susceptible population to infections due to other serological types of Hi and the reevaluation of immunization schedules used by the National Immunization Program. | en |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Controle de Qualidade em Saúde. Departamento de Microbiologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Nacional de Pesquisas Evandro Chagas. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Haemophilus influenzae | en |
| Subject | Haemophilus Vaccines | en |
| Subject | Vaccines, Conjugate | en |
| Subject | Meningitis, Haemophilus | en |
| Subject | Immunization | en |
| DeCS | Haemophilus influenzae | pt_BR |
| DeCS | Vacinas Anti-Haemophilus | pt_BR |
| DeCS | Vacinas Conjugadas | pt_BR |
| DeCS | Infecções por Haemophilus | pt_BR |
| DeCS | Meningite por Haemophilus | pt_BR |
| DeCS | Imunização | pt_BR |
| DeCS | Programas de Imunização | pt_BR |
| e-ISSN | 10.1590/S0100-879X2005000500016 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
