| Author | Vojnov, Lara | |
| Author | Martins, Mauricio A. | |
| Author | Bean, Alexander T. | |
| Author | Santana, Marlon G. Veloso de | |
| Author | Sacha, Jonah B. | |
| Author | Wilson, Nancy A. | |
| Author | Bonaldo, Myrna C. | |
| Author | Galler, Ricardo | |
| Author | Stevenson, Mario | |
| Author | Watkins, David I. | |
| Access date | 2016-08-30T13:44:45Z | |
| Available date | 2016-08-30T13:44:45Z | |
| Document date | 2012 | |
| Citation | VOJNOV. Lara; et al. The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages. JOurnal of Virology, v.86, n.8, p.4682-4687, Apr. 2012. | pt_BR |
| ISSN | 0022-538X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/15518 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Macrófagos | pt_BR |
| Subject in Portuguese | Vírus da Imunodeficiência Símia | pt_BR |
| Subject in Portuguese | AIDS | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Title | The majority of freshly sorted simian immunodeficiency virus (SIV)-specific CD8(+) T cells cannot suppress viral replication in SIV-infected macrophages | pt_BR |
| Type | Article | |
| DOI | 10.1128/JVI.06324-11 | |
| Abstract | Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4(+) T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8(+) T cells that eliminated and suppressed viral replication in SIV-infected CD4(+) T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8(+) T cell-mediated lysis and continue to produce virus over long periods of time. | pt_BR |
| Affilliation | University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Oregon Health Sciences University. Oregon National Primate Research Center. Vaccine and Gene Therapy Institute. Beaverton, Oregin, USA. | pt_BR |
| Affilliation | University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | University of Miami Leonard M. Miller School of Medicine. Miami, Florida, USA. | pt_BR |
| Affilliation | University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA / Wisconsin National Primate Research Center. Madison, Wisconsin, USA. | pt_BR |
| Subject | CD4 T cells | pt_BR |
| Subject | simian immunodeficiency virus (SIV) | pt_BR |
| Subject | SIV-Infected Macrophages | pt_BR |
| Subject | AIDS | pt_BR |
| Subject | CD8 T Cells | pt_BR |
| e-ISSN | 1098-5514 | |
