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THE MAJORITY OF FRESHLY SORTED SIMIAN IMMUNODEFICIENCY VIRUS (SIV)-SPECIFIC CD8(+) T CELLS CANNOT SUPPRESS VIRAL REPLICATION IN SIV-INFECTED MACROPHAGES
Vojnov, Lara et al. | Date Issued: 2012
Author
Vojnov, Lara
Martins, Mauricio A.
Bean, Alexander T.
Santana, Marlon G. Veloso de
Sacha, Jonah B.
Wilson, Nancy A.
Bonaldo, Myrna C.
Galler, Ricardo
Stevenson, Mario
Watkins, David I.
Affilliation
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Oregon Health Sciences University. Oregon National Primate Research Center. Vaccine and Gene Therapy Institute. Beaverton, Oregin, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil.
University of Miami Leonard M. Miller School of Medicine. Miami, Florida, USA.
University of Wisconsin—Madison. Department of Pathology and Laboratory Medicine. Madison, Wisconsin, USA / Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
Abstract
Human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) primarily infect activated CD4(+) T cells but can infect macrophages. Surprisingly, ex vivo tetramer-sorted SIV-specific CD8(+) T cells that eliminated and suppressed viral replication in SIV-infected CD4(+) T cells failed to do so in SIV-infected macrophages. It is possible, therefore, that while AIDS virus-infected macrophages constitute only a small percentage of all virus-infected cells, they may be relatively resistant to CD8(+) T cell-mediated lysis and continue to produce virus over long periods of time.
Keywords in Portuguese
Macrófagos
Vírus da Imunodeficiência Símia
AIDS
HIV
 
Keywords
CD4 T cells
simian immunodeficiency virus (SIV)
SIV-Infected Macrophages
AIDS
CD8 T Cells
 
Publisher
American Society for Microbiology
Citation
VOJNOV. Lara; et al. The Majority of Freshly Sorted Simian Immunodeficiency Virus (SIV)-Specific CD8 T Cells Cannot Suppress Viral Replication in SIV-Infected Macrophages. JOurnal of Virology, v.86, n.8, p.4682-4687, Apr. 2012.
DOI
10.1128/JVI.06324-11
ISSN
0022-538X