Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/15804
Title: Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil
Authors: Delatorre, Edson Oliveira
Bello, Gonzalo
Silva, Walter de Araujo Eyer
Chequer-Fernandez, Saada L.
Morgado, Mariza G.
Fernandez, José Carlos Couto
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Hospital Universitário Gafreé Guinle. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de AIDS e Imunologia Molecular. Rio de Janeiro, RJ, Brasil.
Abstract: HIV-1 CRF02_AG is the most prevalent intersubtype recombinant form worldwide. Six HIV-1 samples from patients living in Rio de Janeiro, Brazil, were subtyped as CRF02_AG at the pol gene between 2004 and 2011. To trace the origin of these viruses, they were compared with 793 CRF02_AG pol sequences of African origin and another four Brazilian CRF02_AG pol sequences previously described. Phylogenetic analysis reveals that there have been at least four introductions of the CRF02_AG clade in Brazil, as signified by the presence of four phylogenetically distinct lineages, probably originated from western African countries (Benin, Ghana, and Guinea-Bissau). At least two CRF02_AG Brazilian lineages were successful in getting established and disseminated throughout the Rio de Janeiro state, with evidence of both horizontal and vertical transmission. Continuous epidemiological surveillance of HIV-1 strains circulating in Brazil is of paramount importance to the early detection of newly emerging viral lineages.
Keywords: HIV-1 strains
Rio de Janeiro
epidemiological surveillance
HIV-1 CRF02_AG
newly emerging viral lineages
keywords: HIV-1
Vigilância epidemiológica
Rio de Janeiro
Linhagens virais emergentes
Issue Date: 2012
Publisher: Mary Ann Liebert
Citation: DELATORRE, Edson Oliveira; et al. Evidence of Multiple Introductions and Autochthonous Transmission of the HIV Type 1 CRF02_AG Clade in Brazil. Aids Research and Human Retroviruses, v.28, n.10, p.1369-1372, 2012.
DOI: 10.1089/aid.2011.0381
ISSN: 0889-2229
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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