Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/16418
Title: Revisiting the Heterogeneous IFN-γ Response of Bacille of Calmette-Guérin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism
Authors: Conceição, Elisabete Lopes
Sampaio, Francisco Soares Nascimento
Schwingel, Paulo Adriano
Oliveira, Evelin S
Rocha, Michael S
Vieira, Igor
Mendes, Carlos M C
Machado, Adelmir Souza
Oliveira, Martha M
Barral Netto, Manoel
Marinho, Jamocyr Moura
Bessa, Theolis Costa Barbosa
Affilliation: Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil / Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil
Universidade Federal do Rio de Janeiro. Faculdade de Medicina. Rio de Janeiro, RJ, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Instituto Gonçalo Moniz. Salvador, BA, Brasil
Escola Bahiana de Medicina e Saúde Pública. Salvador, BA, Brasil / Hospital Santa Izabel. Salvador, BA, Brasil
Abstract: In trials evaluating the immune responses to Bacille of Calmette-Guérin (BCG), the genetic background and the nutritional status are host-related factors that could affect the heterogeneity in these parameters. The IFNG+874 A/T (rs 62559044) polymorphism has been reported to influence the IFN-γ production by BCG-vaccinated individuals challenged in vitro with mycobacterial antigens. The body mass index (BMI) is a proxy for the nutritional status and has been associated both with the susceptibility to tuberculosis and with the IFN-γ response. We show that although the IFNG+874 A/T polymorphism was not associated with the heterogeneity of IFN-γ production in a randomized controlled trial that evaluated long-term immune responses to BCG revaccination previously conducted in Salvador, Bahia, Brazil, the effect of this polymorphism on the observed increase in IFN-γ production among revaccinated subjects was adjusted in individuals with a low BMI.
Keywords: Bacille of Calmette-Guérin
BCG
Vaccina
Nutrition
Tuberculosis
Brasil
Revaccination
Polymorphism
keywords: Bacilo de Calmette-Guérin
BCG
Vacinas
Nutrição
Tuberculose
Brasil
Revacinação
Polimorfismo
Issue Date: 2016
Publisher: Public Library of Science
Citation: CONCEIÇÃO, E. L. et al. Revisiting the Heterogeneous IFN-γ Response of Bacille of Calmette-Guérin (BCG)-Revaccinated Healthy Volunteers in a Randomized Controlled Trial: Effect of the Body Mass Index and of the IFNG+874 A/T Polymorphism. PLoS ONE, v. 11, n. 7, p. e0160149, 2016.
DOI: 10.1371/journal.pone.0160149
ISSN: 1932-6203
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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