Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18447
Title: Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphisms
Authors: Bonaldo, Myrna C.
Gomez, Mariela Martinez
Santos, Alexandre A. C. dos
Abreu, Filipe Vieira Santos de
Brito, Anielly Ferreira de
Miranda, Rafaella Moraes de
Castro, Marcia Gonçalves de
Oliveira, Ricardo Lourenço de
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil / Instituto Federal do Norte de Minas Gerais. MG, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Mosquitos Transmissores de Hematozoários. Rio de Janeiro, RJ, Brasil
Abstract: The current yellow fever (YF) outbreak in Brazil is the most severe recently reported in the country. It has rapidly spread to areas where YF viral activity have not been observed for more than seventy years and vaccine coverage is almost null. Here, we sequenced the whole YF genome of two naturally infected howler-monkeys (Alouatta clamitans) from the Municipality of Domingos Martins, State of Espírito Santo, Brazil. The ongoing-outbreak genome sequences are identical. They clustered in 1E sub-clade (South America I genotype) together with recent Brazilian and Venezuelan strains characterized from infections in humans and non-humans primates. However, we detected eight unique amino acid changes in the viral proteins, which are located in the structural capsid protein (1 change), and the components of viral replicase complex, the NS3 (2 changes) and NS5 (5 changes) proteins, suggesting a potential role in the capacity of viral infection to vertebrate and/or invertebrate hosts and spreading in the ongoing outbreak.
Keywords: yellow fever virus
2017 Brazil outbreak
amino acids changes
keywords: Vpirus da febre amarela
Surto de 2017 no Brasil
alterações de aminoácidos
Issue Date: 2017
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz.
Citation: BONALDO, Myrna C. et al. Genome analysis of yellow fever virus of Brazil ongoing outbreak reveals polymorphism. Mem Inst Oswaldo Cruz. E-pub: 4 Apr 2017.
DOI: 10.1590/0074-02760170134
ISSN: 1678-8080
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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