Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/1865
Title: Synthesis and biological evaluation of substituted a- and b-2,3-dihydrofuran naphthoquinones as potent anticandidal agents
Authors: Freire, Cristina Pessoa Veloso
Ferreira, Sabrina Baptista
Oliveira, Nivea Suely Melo de
Matsuura, Ani Beatriz Jackisch
Gama, Ivson Lelis
Silva, Fernando de C. da
Souza, Maria Cecilia B. V. de
Lima, Emerson Silva
Ferreira, Vitor Francisco
Affilliation: Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.
Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil.
Universidade Federal do Amazonas. Faculdade de Ciências Farmacêuticas. Manaus, AM, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas Maria Deane. Manaus, AM, Brasil.
Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil.
Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Leônidas Maria Deane. Manaus, AM, Brasil.
Universidade Federal Fluminense. Departamento de Química Orgânica. Instituto de Química. Campus do Valonguinho. Niterói, RJ, Brasil.
Abstract: We report herein, the synthesis and antifungal activity of substituted a- and b-dihydrofuran naphthoquinones. These compounds were prepared from readily available lawsone and olefins in the presence of cerium(IV) ammonium nitrate (CAN) and were then evaluated against the following six strains of Candida (C.): C. albicans, C. krusei, C. parapsilosis, C. kefyr, C. tropicalis and C. dubliniensis. In addition to exhibiting low cytotoxicity, the furan naphthoquinones proved to be active against these fungi, indicating that they are important scaffolds and potential novel antifungal agents.
Keywords: Synthesis and Antifungal Activity
Cerium(IV) Ammonium Nitrate (CAN)
Potent Anticandidal Agents
Issue Date: 2010
Citation: FREIRE, Cristina Pessoa Veloso et al. Synthesis and biological evaluation of substituted a- and b-2,3-dihydrofuran naphthoquinones as potent anticandidal agents. Med. Chem. Commun., v. 1, p. 229-232, 2010.
DOI: 10.1039/c0md00074d
Copyright: restricted access
Appears in Collections:AM - ILMD - Artigos de Periódicos

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