Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/18814

Type
Article
Copyright
Restricted access
Embargo date
2030-01-01
Collections
Share

Statistics
Metadata
Show full item record

PROBABLE CORTICOSTEROID-INDUCED REACTIVATION OF LATENT HEPATITIS B VIRUS INFECTION IN AN HIV-POSITIVE PATIENT INVOLVING IMMUNE ESCAPE
Martel, Nora et al. | Date Issued: 2012
Author
Martel, Nora
Cotte, Laurent
Trabaud, Mary-Anne
Trepo, Christian
Zoulim, Fabien
Gomes, Selma A.
Kay, Alan
Affilliation
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Infectious Diseases Unit. Lyon, France.
Hôpital de la Croix-Rousse. Virology Laboratory. Lyon, France.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France / Hôpital de la Croix-Rousse. Hepato-Gastroenterology Unit. Lyon, France.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Virologia Molecular. Rio de Janeiro, RJ, Brasil.
Centre de Recherche en Cancérologie de Lyon (CRCL). INSERM, U1052, CNRS, UMR 5286, UCBL1, S_1052. France.
Abstract
We describe a patient infected with human immunodeficiency virus who possessed a serological profile suggesting a previous cleared acute hepatitis B virus (HBV) infection, including high levels of antibodies against HBV surface antigen (anti-HBs). Following the administration of inhaled glucocorticosteroids combined with protease inhibitor-based antiretroviral treatment, the patient developed an unexpected severe acute hepatitis despite persistence of anti-HBs. A genotype A2 strain emerged with 2 major mutations in the S gene, sK122R and sD144E. Molecular and biological analyses strongly suggested reactivation of a latent HBV infection. The importance and the molecular basis of these 2 epitopes in immune-escape mechanisms and host-virus interactions are discussed.
Keywords in Portuguese
Vírus da Hepatite B
HIV
Pacientes
Corticosteróide
 
Keywords
Hepatitis B Virus Infection
HIV-Positive Patient
Corticosteroid
 
Publisher
Oxford University Press
Citation
MARTEL, Nora; et al. Probable Corticosteroid-Induced Reactivation of Latent Hepatitis B Virus Infection in an HIV-Positive Patient Involving Immune Escape. The Journal of Infectious Diseases, v.205, p.1757–61, 2012.
DOI
10.1093/infdis/jis268
ISSN
0022-1899