Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20592
Title: Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery
Authors: Andrade, Antônio Ricardo de
Cotrim, Helma Pinchemel
Alves, Erivaldo
Soares, Daniela
Rocha, Raquel
Almeida, Alessandro de Moura
Almeida, Carolina de Godoy
Freitas, Luiz Antonio Rodrigues de
Affilliation: Universidade Federal da Bahia. Postgraduate Course in Medicine and Health. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil
Center for the Surgical Treatment of Obesity. Surgeon. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Programa de Pós Graduação em Medicina e Saúde. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Escola de Medicina. Salvador, BA, Brasil
Universidade Federal da Bahia. Salvador, BA, Brasil / Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: associated with NAFLD, and bariatric surgery (BAS) is traditionally indicated for the treatment of severely obese individuals. Here, we discuss the behavior and prognosis of this liver disease following post-surgical weight loss. Aim: To evaluate the influence of the BAS on the clinical and biochemical parameters of NAFLD in severely obese patients. Methodology: An intervention study included obese individuals (BMI≥ 35kg/m2), who had been submitted to liver biopsy during BAS and had NAFLD. HAIR (hypertension, ALT and insulin resistance and BAAT (BMI, ALT, age and triglycerides) scores and FLI (Fatty Liver Index) were used to compare the patients at the time of surgery, and 12-30 months following weight loss. Results: From October 2004 to September 2007, 122 patients were diagnosed with NAFLD, 40 of whom agreed to participate in the study. The mean age was 37.7 ± 12.5 years, 60% were women and 80% had steatohepatitis (NASH) with fibrosis upon analysis of the liver biopsy performed during BAS. Mean weight loss was 46.0 ± 2.0 kg. After 21 ± 5.8 months of follow-up, a significant improvement was found in all the variables analyzed (79.3% according to the HAIR scores, 95.2% as measured by the BAAT score and 72.5% by the FLI. Conclusion: The results suggest that treatment of obesity by bariatric surgery may influence the prognosis of NAFLD. In addition to weight loss, we observed improvement in the clinical and biochemical parameters related to NAFLD, such as anthropometrics index, hypertension, aminotransferases, triglycerides and insulin resistance.
Keywords: Nonalcoholic steatohepatitis (NASH)
Morbid obesity
Metabolic syndrome
Insulin resistance
Obesity
keywords: Esteato-hepatite não alcoólica
Obesidade mórbida
Síndrome X metabólica
Resistência à insulina
Obesidade
Issue Date: 2009
Publisher: Springer Verlag
Citation: ANDRADE, A. R. et al. Nonalcoholic fatty liver disease in severely obese individuals: The influence of bariatric surgery. Annals of Hepatology, v. 7, n. 4, p. 364-368, 2008.
ISSN: 0939-5555
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos

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