Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/20726
Title: Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae)
Authors: Ferraz, Rosana Paula Cruz
Cardoso, Gabriella M B
Silva, Thanany Brasil da
Fontes, José Eraldo do Nascimento
Prata, Ana Paula do Nascimento
Carvalho, Adriana Andrade
Moraes, Manoel O
Pessoa, Claudia do Ó
Costa, Emmanoel Vilaça
Bezerra, Daniel Pereira
Affilliation: Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Biology. São Cristóvão, SE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Ceará. School of Medicine. Department of Physiology and Pharmacology. Fortaleza, CE, Brazil
Federal University of Sergipe. Department of Chemistry. São Cristóvão, SE, Brazil
Federal University of Sergipe. Department of Physiology. São Cristóvão, SE, Brazil
Abstract: The aim of this study was to investigate the chemical composition and anticancer effect of the leaf essential oil of Xylopia frutescens in experimental models. The chemical composition of the essential oil was analysed by GC/FID and GC/MS. In vitro cytotoxic activity of the essential oil was determined on cultured tumour cells. In vivo antitumour activity was assessed in Sarcoma 180-bearing mice. The major compounds identified were (E)-caryophyllene (31.48%), bicyclogermacrene (15.13%), germacrene D (9.66%), δ-cadinene (5.44%), viridiflorene (5.09%) and α-copaene (4.35%). In vitro study of the essential oil displayed cytotoxicity on tumour cell lines and showed IC50 values ranging from 24.6 to 40.0 μg/ml for the NCI-H358M and PC-3M cell lines, respectively. In the in vivo antitumour study, tumour growth inhibition rates were 31.0-37.5%. In summary, the essential oil was dominated by sesquiterpene constituents and has some interesting anticancer activity.
Keywords: Xylopia frutescens
Annonaceae
Essential oil
Chemical composition
Antitumour
keywords: Xylopia frutescens
Annonaceae
Óleo essencial
Composição química
Antitumour
Issue Date: 2013
Publisher: Elsevier
Citation: FERRAZ, R. P. C. et al. Antitumour properties of the leaf essential oil of Xylopia frutescens Aubl. (Annonaceae). Food Chemistry, v. 141, p. 196–200, 2013.
Description: Bezerra, Daniel Pereira “Documento produzido em parceria ou por autor vinculado à Fiocruz, mas não consta à informação no documento”.
DOI: 10.1016/j.foodchem.2013.02.114
ISSN: 0308-8146
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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