| Author | Bonaldo, Myrna C. | |
| Author | Martins, Mauricio A. | |
| Author | Rudersdorf, Richard | |
| Author | Mudd, Philip A. | |
| Author | Sacha, Jonah B. | |
| Author | Piaskowski, Shari M. | |
| Author | Neves, Patrícia C. Costa | |
| Author | Santana, Marlon G. Veloso de | |
| Author | Vojnov, Lara | |
| Author | Capuano, Saverio | |
| Author | Rakasz, Eva G. | |
| Author | Wilson, Nancy A. | |
| Author | Fulkerson, John | |
| Author | Sadoff, Jerald C. | |
| Author | Watkins, David I. | |
| Author | Galler, Ricardo | |
| Access date | 2017-09-12T13:05:30Z | |
| Available date | 2017-09-12T13:05:30Z | |
| Document date | 2010 | |
| Citation | BONALDO, Myrna C. et al. Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8 T-Cell Responses in Rhesus Macaques. Journal of Virology, v.84, n.8, p.3699-3706, Apr. 2010. | pt_BR |
| ISSN | 0022-538X | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/20954 | |
| Language | eng | pt_BR |
| Publisher | American Society for Microbiology | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Febre amarela | pt_BR |
| Subject in Portuguese | Vacina | pt_BR |
| Subject in Portuguese | Macacos Rhesus | pt_BR |
| Subject in Portuguese | HIV | pt_BR |
| Title | Recombinant yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 gag induces SIV-specific CD8+ T-cell responses in rhesus macaques | pt_BR |
| Type | Article | |
| DOI | 10.1128/JVI.02255-09 | |
| Abstract | Here we describe a novel vaccine vector for expressing human immunodeficiency virus (HIV) antigens. We show that recombinant attenuated yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 Gag sequences can be used as a vector to generate SIV-specific CD8(+) T-cell responses in the rhesus macaque. Priming with recombinant BCG expressing SIV antigens increased the frequency of these SIV-specific CD8(+) T-cell responses after recombinant YF17D boosting. These recombinant YF17D-induced SIV-specific CD8(+) T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4(+) T cells. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA. | pt_BR |
| Affilliation | Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA. | pt_BR |
| Affilliation | Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA. | pt_BR |
| Subject | Yellow Fever Virus 17D | pt_BR |
| Subject | Vaccine | pt_BR |
| Subject | Rhesus Macaques | pt_BR |
| Subject | Immunodeficiency Virus | pt_BR |
| Subject | CD8 T cells | pt_BR |
| e-ISSN | 1098-5514 | |
| xmlui.metadata.dc.subject.ods | 03 Saúde e Bem-Estar | |
