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RECOMBINANT YELLOW FEVER VACCINE VIRUS 17D EXPRESSING SIMIAN IMMUNODEFICIENCY VIRUS SIVMAC239 GAG INDUCES SIV-SPECIFIC CD8+ T-CELL RESPONSES IN RHESUS MACAQUES
Bonaldo, Myrna C. et al. | Date Issued: 2010
Author
Bonaldo, Myrna C.
Martins, Mauricio A.
Rudersdorf, Richard
Mudd, Philip A.
Sacha, Jonah B.
Piaskowski, Shari M.
Neves, Patrícia C. Costa
Santana, Marlon G. Veloso de
Vojnov, Lara
Capuano, Saverio
Rakasz, Eva G.
Wilson, Nancy A.
Fulkerson, John
Sadoff, Jerald C.
Watkins, David I.
Galler, Ricardo
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ. Brasil.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA.
University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
University of Wisconsin. Department of Pathology. Laboratory Medicine. Madison, Wisconsin, USA / University of Wisconsin. Wisconsin National Primate Research Center. Madison, Wisconsin, USA.
Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA.
Aeras Global TB Vaccine Foundation. Rockville, Maryland, USA.
Abstract
Here we describe a novel vaccine vector for expressing human immunodeficiency virus (HIV) antigens. We show that recombinant attenuated yellow fever vaccine virus 17D expressing simian immunodeficiency virus SIVmac239 Gag sequences can be used as a vector to generate SIV-specific CD8(+) T-cell responses in the rhesus macaque. Priming with recombinant BCG expressing SIV antigens increased the frequency of these SIV-specific CD8(+) T-cell responses after recombinant YF17D boosting. These recombinant YF17D-induced SIV-specific CD8(+) T cells secreted several cytokines, were largely effector memory T cells, and suppressed viral replication in CD4(+) T cells.
Keywords in Portuguese
Febre amarela
Vacina
Macacos Rhesus
HIV
 
Keywords
Yellow Fever Virus 17D
Vaccine
Rhesus Macaques
Immunodeficiency Virus
CD8 T cells
 
Publisher
American Society for Microbiology
Citation
BONALDO, Myrna C. et al. Recombinant Yellow Fever Vaccine Virus 17D Expressing Simian Immunodeficiency Virus SIVmac239 Gag Induces SIV-Specific CD8 T-Cell Responses in Rhesus Macaques. Journal of Virology, v.84, n.8, p.3699-3706, Apr. 2010.
DOI
10.1128/JVI.02255-09
ISSN
0022-538X