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BIOLOGICAL ROLES OF PEPTIDASES IN TRYPANOSOMATIDS
Vermelho, Alane Beatriz et al. | Date Issued: 2010
Author
Vermelho, Alane Beatriz
Branquinha, Marta Helena
d`Avila-Levy, Claudia M.
Santos, André Luis Souza dos
Dias, Edilma Paraguai de Souza
Melo, Ana Cristina Nogueira de
Affilliation
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Bioquímica e Biologia Celular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Rio de Janeiro. Centro de Ciências da Saúde. Instituto de Microbiologia Prof. Paulo de Góes. Rio de Janeiro, RJ, Brasil.
Abstract
In this review, we report the recent developments in the characterization of peptidases and their possible biological functions in the Trypanosomatidae family. The focus will be on peptidases from Trypanosoma cruzi, Leishmania spp., African trypanosomes and plant and insect trypanosomatids. There are numerous events in parasite development where the involvement of peptidases has been established, and they will be approached in the present review. Also in this review we will discuss the central roles have been proposed for peptidases in diverse processes such as virulence, host cell interaction and invasion, catabolism of host proteins, differentiation, cell cycle progression and both stimulation and evasion of host immune responses.
Keywords in Portuguese
Peptidases
Tripanosomatídeos
Metaloproteases 
peptidases de serina
Peptidases de cisteína
 
Keywords
Peptidases
Trypanosomatids
Cruzipain
Cysteine peptidases
Serina peptidases
Metallopeptidases
 
Publisher
Bentham Open
Citation
VERMELHO, Alane Beatriz; et al. Biological roles of Peptidases in Trypanosomatids. The Open Parsitology Journal, v.4, p.5-23, 2010.
ISSN
1874-4214