Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/21078
Title: Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production
Authors: Pinto, Larissa G.
Talbot, Jhimmy
Peres, Raphael S.
Franca, Rafael F.
Ferreira, Sérgio H.
Ryffel, Bernhard
Aves-Filho, José Carlos F.
Figueiredo, Florêncio
Cunha, Thiago M.
Cunha, Fernando Q.
Affilliation: Fundação Oswaldo Cruz. Instituto Aggeu Magalhães. Recife, PE, Brasil
Abstract: Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction of cartilage and bone. IL-22 is a key effector molecule that plays a critical role in autoimmune diseases. However, the function of IL-22 in the pathogenesis of RA remains controversial. In this study, we investigated the role of IL-22 in the early phase of antigen-induced arthritis (AIA) in mice.
Keywords: Animals
Antigens
Apoptosis Regulatory Proteins
Arthralgia
Arthritis, Experimental
Cell Movement
Enzyme-Linked Immunosorbent Assay
Enzyme-Linked Immunosorbent Assay
Gene Expression
Interleukin-1beta
Knee Joint
Mice, Inbred C57BL
Mice, Knockout
Neutrophils
Reverse Transcriptase Polymerase Chain Reaction
Synovial Membrane
Synovitis
Zymosan
keywords: Artrite Experimental
Interleucina-1beta
Interleucinas
Articulação do Joelho
DeCS: Artrite Experimental
genética
metabolismo
imunologia
Interleucina-1beta
Interleucinas
Animais
Antígenos
Proteínas Reguladoras de Apoptose
Arthralgia
Movimento Celular
Ensaio de Imunoadsorção Enzimática
Expressão Gênica
Articulação do Joelho
Camundongos Endogâmicos C57BL
Camundongos Knockout
Neutrófilos
Reação em Cadeia da Polimerase Via Transcriptase Reversa
Membrana Sinovial
Sinovite
Zimosan
Issue Date: 2015
Citation: PINTO, L. G. et al. Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production. Arthritis Research & Therapy, v. 17, p. 235, 2 set. 2015.
DOI: 10.1186/s13075-015-0759-2
ISSN: 1478-6362
Copyright: open access
Appears in Collections:PE - IAM - Artigos de Periódicos

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