Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/22815
Title: First report of the Phe1534Cys kdr mutation in natural populations of Aedes albopictus from Brazil
Authors: Aguirre-Obando, Oscar Alexander
Martins, Ademir Jesus
Silva, Mário Antônio Navarro
Affilliation: Universidade Federal do Paraná. Departamento de Zoologia. Setor de Ciências Biológicas. Laboratório de Entomologia Médica e Veterinária. Curitiba, Paraná, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ. Brasil / Instituto Nacional de Ciência e Tecnologia em Entomologia Molecular. Rio de Janeiro, RJ, Brasil.
Universidade Federal do Paraná. Departamento de Zoologia. Setor de Ciências Biológicas. Laboratório de Entomologia Médica e Veterinária. Curitiba, Paraná, Brasil.
Abstract: Knockdown resistance (kdr), caused by alterations in the voltage-gated sodium channel (NaV), is one of the mechanisms responsible for pyrethroid (PY) resistance. In the Asian tiger mosquito, Aedes albopictus, at least four different mutations were described in the IIIS6 NaV segment in populations from Asia, North America and Europe. In contrast, in Aedes aegypti at least 12 non-synonymous mutations have been reported at nine different codons, mostly in the IIS6 and IIIS6 NaV segments. The Phe1534Cys kdr mutation in the IIIS6 NaV segment is the most prevalent in populations of Ae. aegypti worldwide, also found in Ae. albopictus from Singapore. Herein, we investigated the DNA diversity corresponding to the IIS6 and IIIS6 NaV segments in natural populations of Ae. albopictus from Brazil.
Keywords: Allele-specific PCR
Chikungunya
Dengue
Pyrethroid resistance
Vector control
Voltage-gated-sodium channel
Zika
keywords: Dengue
Zika
Chikungunya
Controle de vetores
Resistência à piretróide
Canais de Sódio
Alelos
Reação em Cadeia da Polimerase
Issue Date: 2017
Publisher: BioMed Central
Citation: AGUIRRE-OBANDO, Oscar Alexander; MARTINS, Ademir Jesus; SILVA, Mário Antônio Navarro. First report of the Phe1534Cys kdr mutation in natural populations of Aedes albopictus from Brazil. Parasites & Vectors, v10:160, 10p, 2017.
DOI: 10.1186/s13071-017-2089-5
ISSN: 1756-3305
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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