Title:	Biological and molecular characterization of clonal populations of Trypanosoma cruzi strains: 21SF – Biodeme Type II and Colombian strain – Biodeme Type III, isolated from infected mice, treated with Benznidazole and not cured
Authors:	Morais, Isa Rita Brito de Guerreiro, Marcos Lázaro da Silva Patriota, G. S. Q Santos, Viviane Corrêa Macedo, Andrea Mara Andrade, Sonia Gumes
Affilliation:	Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil Universidade Federal de Minas Gerais. Departamento de Bioquimica e IMunologia. Belo Horizonte, MG, Brazil Universidade Federal de Minas Gerais. Departamento de Bioquimica e IMunologia. Belo Horizonte, MG, Brazil Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Abstract:	Introduction: Different strains and clones of Trypanosoma cruzi present different degrees of susceptibility to treatment with chemotherapic drugs. Several studies have been developed to evaluate the response to different drugs concerning the strains prototypes of Biodemes Types I, II and III according to the biological characterization. Results have shown that the strains prototypes of the Biodeme Type I (Y and Peruvian strains) disclosed a high susceptibility to treatment with Benznidazole and Nifurtimox; strains of the Biodeme Type II (prototype: the 21SF strain) showed a medium susceptibility; the strains of the Biodeme Type III (Colombian strain) were highly resistant
Keywords:	Trypanosoma cruzi Chemotherapic Drugs Mice Animals
keywords:	Trypanosoma cruzi Quimioterápicos Drogas Camundogos Animais
Issue Date:	2012
Publisher:	Sociedade Brasileira de Medicina Tropical
Citation:	MORAIS, I. R. B. et al. Biological and molecular characterization of clonal populations of Trypanosoma cruzi strains: 21SF – Biodeme Type II and Colombian strain – Biodeme Type III, isolated from infected mice, treated with Benznidazole and not cured. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.
Copyright:	open access
Appears in Collections:	BA - IGM - Trabalhos Apresentados em Eventos

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