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BIOLOGICAL AND MOLECULAR CHARACTERIZATION OF CLONAL POPULATIONS OF TRYPANOSOMA CRUZI STRAINS: 21SF – BIODEME TYPE II AND COLOMBIAN STRAIN – BIODEME TYPE III, ISOLATED FROM INFECTED MICE, TREATED WITH BENZNIDAZOLE AND NOT CURED
Morais, Isa Rita Brito de et al. | Date Issued: 2012
Author
Morais, Isa Rita Brito de
Guerreiro, Marcos Lázaro da Silva
Patriota, G. S. Q
Santos, Viviane Corrêa
Macedo, Andrea Mara
Andrade, Sonia Gumes
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Universidade Federal de Minas Gerais. Departamento de Bioquimica e IMunologia. Belo Horizonte, MG, Brazil
Universidade Federal de Minas Gerais. Departamento de Bioquimica e IMunologia. Belo Horizonte, MG, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Laboratório de Chagas Experimental Autoimunidade e Imunologia Celular. Salvador, BA, Brasil
Abstract
Introduction: Different strains and clones of Trypanosoma cruzi present different degrees of susceptibility to treatment with chemotherapic drugs. Several studies have been developed to evaluate the response to different drugs concerning the strains prototypes of Biodemes Types I, II and III according to the biological characterization. Results have shown that the strains prototypes of the Biodeme Type I (Y and Peruvian strains) disclosed a high susceptibility to treatment with Benznidazole and Nifurtimox; strains of the Biodeme Type II (prototype: the 21SF strain) showed a medium susceptibility; the strains of the Biodeme Type III (Colombian strain) were highly resistant
Keywords in Portuguese
Trypanosoma cruzi
Quimioterápicos
Drogas
Camundogos
Animais
 
Keywords
Trypanosoma cruzi
Chemotherapic
Drugs
Mice
Animals
 
Publisher
Sociedade Brasileira de Medicina Tropical
Citation
MORAIS, I. R. B. et al. Biological and molecular characterization of clonal populations of Trypanosoma cruzi strains: 21SF – Biodeme Type II and Colombian strain – Biodeme Type III, isolated from infected mice, treated with Benznidazole and not cured. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.