Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/23597

Type
Papers presented at events
Copyright
Open access
Sustainable Development Goals
03 Saúde e Bem-Estar
Collections
Share

Statistics
Metadata
Show full item record

IN VITRO AND IN VIVO EVALUATION ANTI-TRYPANOSOMA CRUZI ACTIVITY OF N-ACYLHYDRAZONES OXADIAZOLES
Meira, Cássio Santana et al. | Date Issued: 2012
Author
Meira, Cássio Santana
Guimarães, Elisalva Teixeira
Bastos, Tanira Matutino
Castro, Murilo Fagundes de
Moreira, Diogo Rodrigo de Magalhães
Santos Filho, J. M. dos
Soares, Milena Botelho Pereira
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil
Federal University of Pernambuco. Department of Pharmaceutical Sciences. Recife, PE, Brazil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Hospital São Rafael. Center of Biotechnology and Cell Therapy. Salvador, BA, Brazil
Abstract
Chagas disease, or American trypanosomiasis, is caused by the flagellate protozoan Trypanosoma cruzi. One century after its discovery, Chagas disease still remains a major health problem in Latin America. Treatment is based on benznidazole that have toxic effects and limited efficacy. Therefore, new chemotherapeutic agents are urgently needed. In this context, the effects of sixteen N-acylhydrazone oxadiazoles were evaluated as potential candidates for anti-T. cruzi agents
Keywords in Portuguese
Trypanosoma cruzi
Doença de Chagas
Saude publica
Tratamento
Microscopia eletrônica
 
Keywords
Trypanosoma cruzi
Chagas disease
Public health
Treatment
Electron microscopy
 
Publisher
Sociedade Brasileira de Medicina Tropical
Citation
MEIRA, C. S. et al. In vitro and in vivo evaluation anti-Trypanosoma cruzi activity of N-acylhydrazones oxadiazoles. In: CONGRESSO INTERNACIONAL DE MEDICINA TROPICAL E MALÁRIA, 18 e CONGRESSO DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL, 48., 2012, Rio de Janeiro. Resumos... Rio de Janeiro: Sociedade Brasileira de Medicina Tropical, 2012.