Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/24794
Title: Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the Risk for Obesity
Authors: Fonseca, Ana Carolina Proença da
Ochioni, Alan Cleveland
Martins, Raisa da Silva
Zembrzuski, Verônica Marques
Campos Junior, Mario
Ramos, Vivianne Galante
Carneiro, João Regis Ivar
Nogueira Neto, José Firmino
Cabello, Pedro Hernan
Cabello, Giselda Maria Kalil
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
Universidade Grande Rio. Laboratório de Gnética Humana. Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
Universidade Grande Rio. Laboratório de Gnética Humana. Rio de Janeiro, Brasil.
Universidade Federal do Rio de Janeiro. Hospital Universitário Clementino Fraga Filho. Rio de Janeiro, RJ, Brasil
Universidade do Estado do Rio de Janeiro. Departamento e Laboratório de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil / Universidade Grande Rio. Laboratório de Gen[etica Humana. Rio de Janeiro, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Humana. Rio de Janeiro, RJ, Brasil.
Abstract: Obesity is the most common nutritional disorder. This disease is a multifactorial disease influenced by environmental and genetic factors. This study investigated the relationship between common variants of adiponectin (ADIPOQ), retinoic acid receptor responder 2 (RARRES2), and peroxisome proliferator-activated receptor-γ coativator-1 (PPARGC1) and obesity-related traits and susceptibility. A total of 167 individuals with obesity and 165 normal-weight subjects were recruited. Genotype frequencies of rs182052 in ADIPOQ differed significantly between the groups. Genotype AA was observed at a higher frequency in case than in control subjects. Association analysis showed that the A allele was a risk factor for obesity. This polymorphism was associated with body weight, body mass index (BMI), and waist circumference. After stratification by BMI, eutrophic individuals with AA or AG genotypes had higher body weights and waist circumferences than those with GG genotypes. In the case group, no associations were observed, except for stratified subjects with morbid obesity that exhibited a progressive increase of body weight, BMI, and waist circumference when rs182052 A was present. No associations were observed between SNPs in RARRES2 and PPARGC1 and obesity or any other studied variables. The rs182052 polymorphism in ADIPOQ is associated with a higher risk for obesity and obesity-related parameters.
Keywords: Obesity
adiponectin
Retinoic Acid Receptor Responder 2
proliferator-activated receptor-γ coativator-1
keywords: Obesidade
Adiponectina 
Fatores de risco
receptor de ácido retinoico
Issue Date: 2017
Publisher: Hindawi Publishing Corporation
Citation: FONSECA, Ana Carolina Proença da; et al. Adiponectin, Retinoic Acid Receptor Responder 2, and Peroxisome Proliferator-Activated Receptor-γ Coativator-1 Genes and the risk for obesity. Disease Markers, Volume 2017, Article ID 5289120, 8p, 2017.
DOI: 10.1155/2017/5289120
ISSN: 0278-0240
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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