Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27985
Title: Seizures as a Complication of Congenital Zika Syndrome in Early Infancy
Authors: Oliveira Filho, Jamary
Felzemburgh, Ridalva Dias Martins
Costa, Federico
Nery Júnior, Nivison Ruy Rocha
Mattos, Adriana
Henriques, Daniele Freitas
Ko, Albert Icksang
For The Salvador Zika Response Team
Affilliation: Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, Brasil
Universidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Hospital Geral Roberto Santos. Secretaria Estadual da Saúde da Bahia. Salvador, BA, Brasil
Instituto Evandro Chagas. Belem, PA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut
For The Salvador Zika Response Team
Abstract: Zika virus transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 ± 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures (P < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1-23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment.
Keywords: Zika
Zika Virus
Transmission
Microcephaly
Epilepsy
Brazil
Children
keywords: Zika
Virus Zika
Transmissão
Microcefalia
Epilepsia
Brasil
Crianças
Issue Date: 2018
Publisher: American Society of Tropical Medicine and Hygiene
Citation: OLIVEIRA FILHO, J. et al. Seizures as a Complication of Congenital Zika Syndrome in Early Infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860–1862, 2018.
DOI: 10.4269/ajtmh.17-1020
ISSN: 0002-9637
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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