Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/27985
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dc.contributor.authorOliveira Filho, Jamary
dc.contributor.authorFelzemburgh, Ridalva Dias Martins
dc.contributor.authorCosta, Federico
dc.contributor.authorNery Júnior, Nivison Ruy Rocha
dc.contributor.authorMattos, Adriana
dc.contributor.authorHenriques, Daniele Freitas
dc.contributor.authorKo, Albert Icksang
dc.contributor.authorFor The Salvador Zika Response Team
dc.date.accessioned2018-08-07T15:44:32Z
dc.date.available2018-08-07T15:44:32Z
dc.date.issued2018
dc.identifier.citationOLIVEIRA FILHO, J. et al. Seizures as a Complication of Congenital Zika Syndrome in Early Infancy. American Journal of Tropical Medicine and Hygiene, v. 98, n. 6, p. 1860–1862, 2018.
dc.identifier.issn0002-9637
dc.identifier.urihttps://www.arca.fiocruz.br/handle/icict/27985
dc.description.sponsorshipNIH Grants RO1 NS064905, NIH R01 AI052473, U01 AI088752, and R25 TW009338, and the Oswaldo Cruz Foundation
dc.language.isoeng
dc.publisherAmerican Society of Tropical Medicine and Hygiene
dc.rightsopen access
dc.subject.otherZika
dc.subject.otherVirus Zika
dc.subject.otherTransmissão
dc.subject.otherMicrocefalia
dc.subject.otherEpilepsia
dc.subject.otherBrasil
dc.subject.otherCrianças
dc.titleSeizures as a Complication of Congenital Zika Syndrome in Early Infancy
dc.typeArticle
dc.identifier.doi10.4269/ajtmh.17-1020
dc.description.abstractenZika virus transmission in Brazil was linked to a large outbreak of microcephaly but less is known about longer term anthropometric and neurological outcomes. We studied a cohort of infants born between October 31, 2015, and January 9, 2016, in a state maternity hospital, followed up for 101 ± 28 days by home visits. Microcephaly (< 2 standard deviations, Intergrowth standard) occurred in 62 of 412 (15%) births. Congenital Zika syndrome (CZS) was diagnosed in 29 patients. Among CZS patients, we observed a significant gain in anthropometric measures (P < 0.001) but no significant gain in percentile for these measures. The main neurological outcome was epilepsy, occurring in 48% of infants at a rate of 15.6 cases per 100 patient-months, frequently requiring multiple anti-seizure medications. The cumulative fatality rate was 7.4% (95% confidence interval: 2.1-23.4%). Health-care professionals should be alerted on the high risk of epilepsy and death associated with CZS in early infancy and the need to actively screen for seizures and initiate timely treatment.
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Postgraduate Program in Health Sciences. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, Brasil
dc.creator.affilliationUniversidade Federal da Bahia. Faculdade de Medicina da Bahia. Instituto de Saúde Coletiva. Escola de Enfermagem. Salvador, BA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
dc.creator.affilliationHospital Geral Roberto Santos. Secretaria Estadual da Saúde da Bahia. Salvador, BA, Brasil
dc.creator.affilliationInstituto Evandro Chagas. Belem, PA, Brasil
dc.creator.affilliationFundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil / Yale School of Public Health. Department of Epidemiology of Microbial Diseases. New Haven, Connecticut
dc.creator.affilliationFor The Salvador Zika Response Team
dc.subject.enZika
dc.subject.enZika Virus
dc.subject.enTransmission
dc.subject.enMicrocephaly
dc.subject.enEpilepsy
dc.subject.enBrazil
dc.subject.enChildren
Appears in Collections:BA - IGM - Artigos de Periódicos

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