Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2818
Title: On the presence of hepatic stellate cells in portal spaces
Authors: Fonseca, Yannick de Oliveira
Lima, Camila Bião
Santos, Elisângela Trindade
Andrade, Zilton de Araújo
Affilliation: Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil
Abstract: Previous studies in mice with hypervitaminosis A have demonstrated that fat-storing cells (hepatic stellate cells- HSCs) participate in schistosomal granuloma fibrogenesis. The origin of such cells in portal areas, away from the Disse spaces, was herein investigated. HSCs were identified in frozen sections of the liver by means of Sudan III staining. They appeared as red-stained cells disposed along the sinusoids of normal mice, but were never found within portal spaces. However, in the chronically inflamed portal spaces of Capillaria hepatica-infected mice, Sudan III-positive cells were frequently present among leukocytes and fibroblast-like cells. Thus, there are no resident HSCs in portal spaces, but their presence there in chronic inflammatory processes indicates that they are able to migrate from peri-sinusoidal areas in order to reach the portal areas
Keywords: Hepatic stelate cells
Portal fibrosis
Portal myofibroblasts
keywords: Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
Histocitoquímica
Animais
Camundongos
Ratos Wistar
DeCS: Espaço Extracelular
Hepatócitos
Cirrose Hepática
Sistema Porta
Issue Date: 2011
Citation: FONSECA, Y. de O. et al. On the presence of hepatic stellate cells in portal spaces. Memórias do Instituto Oswaldo Cruz, v. 100, n. 3, p. 289-291, 2005.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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