Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/2820
Title: Imaging exams of bone lesions in patients with diffuse cutaneous leishmaniasis (DCL)
Authors: Costa, Af Ali Uthant Moreira Lima da
Saldanha, Ana Cristina Rodrigues
Leite, Bruno M. C.
Ramos, Bruno
Junior, Ibraim A.
Noronha, Almério Libório Lopes de
Bafica, Andre Luiz Barbosa
Barral, Aldina Maria Prado
Corbett, Carlos Eduardo Pereira
Costa, Jackson Mauricio Lopes
Affilliation: Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil.
Federal University of Maranhão. Nucleus of Tropical Pathology and Social Medicine. São Luís, MA, Brasil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Nuclear Medicine Service. Nuclear Maranhão Clinic. São Luis, MA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
University of São Paulo. Laboratory of Immunopathology (LIM-50). São Paulo, SP, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisa Gonçalo Moniz. Salvador, BA, Brazil.
Abstract: We studied bone lesion alterations in three patients with diffuse cutaneous leishmaniasis (DCL) by imaging exams (radiography and scintigraphy) and histopathology. Two patients had bone lesions of distal extremities of hands and feet, and one infiltrating plaques in the skin. The study was conducted at three specialized centers (Presidente Dutra Hospital/Nucleus of Tropical Pathology, UFMA-MA; Gonc¸alo Moniz Research Center-FIOCRUZ-BA; Laboratory of Pathology of Infectious Diseases (LIM-50), University of S˜ao Paulo, SP). Three-phase bone scintigraphy demonstrated high sensitivity and specificity for bone lesions, showing increased uptake of the radiopharmaceutical at sites of active lesions. In contrast, radiography demonstrated lytic lesions, cortical destruction and local osteopenia of the bone extremeties in two patients. Histopathological analysis showed sequestration with presence of amastigote forms of Leishmania (osteomyelitis), mononuclear cells and macrophages containing amastigote forms of Leishmania in one patient. These preliminary data indicate that imaging exams (radiography and scintigraphy) are important in the evaluation of bone lesions in diffuse cutaneous leishmaniasis and should be included in the routine histopathological diagnosis of the disease and follow-up of bone lesions
Keywords: Diffuse cutaneous Leishmaniasis
Bone alterations
Scintigraphy
Imaging exams
keywords: Adolescente
Adulto
Osso e Ossos
Feminino
Humanos
Leishmaniose Tegumentar Difusa
Masculino
Issue Date: 2004
Citation: COSTA, Af Ali Uthant Moreira Lima da et al. Imaging exams of bone lesions in patients with diffuse cutaneous leishmaniasis (DCL). Acta Tropica, v.96, n. 1, p. 9-15, 2005.
DOI: doi:10.1016/j.actatropica.2005.06.016
ISSN: 1873-6254
Copyright: open access
Appears in Collections:BA - IGM - Artigos de Periódicos

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