Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/29951
Title: Complete Genome Sequence of Central Africa Human T-Cell Lymphotropic Virus Subtype 1b
Authors: Zanella, Louise
Otsuki, Koko
Marin, Michel Abanto
Bendet, Izidro
Vicente, Ana Carolina
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.
Sérgio Franco Medicina Diagnóstica. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Genética Molecular de Microrganismos. Rio de Janeiro, RJ. Brasil.
Abstract: Human T-lymphotropic virus type 1 (HTLV-1) has a global spread, and it is estimated that around 20 million persons are infected. Seven major genetic subtypes are recognized. However, there are complete genomes only from the HTLV-1a (cosmopolitan) and HTLV-1c (Melanesian) subtypes. Here, the first full-length genome of an HTLV-1b strain, a subtype so far restricted to Central African countries, is revealed. The genome size of HTLV-1b SF26, a strain isolated in Brazil, was determined to be 8,267 bp. The genomic analysis showed that all characteristic regions and genes of a prototypic HTLV-1 virus are conserved. This genome can provide information for further studies on the evolutionary history and pathogenic potential of this human oncovirus.
Keywords: Complete Genome Sequence
Human T-Cell
Lymphotropic Virus Subtype 1b
Central Africa
keywords: Sequência Completa do Genoma
Subtipo do Vírus Linfotrópico
Vírus Linfotrópico de Células T Humana 1b
África Central
Issue Date: 2012
Publisher: American Society for Microbiology
Citation: ZANELLA, Louise; et al. Complete Genome Sequence of Central Africa Human T-Cell Lymphotropic Virus Subtype 1b. Journal of Virology, v.86, n.22, p.12451, Nov. 2012.
DOI: 10.1128/JVI.02258-12
ISSN: 0022-538X
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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