Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30600
Title: Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.)
Authors: Kochunov, Peter
Wey, Hsiao-Ying
Fox, Peter
Lancaster, Jack
Davis, Michael
Wang, Danny
Lin, Ai-Ling
Bastarrachea, Raul
Andrade, Marcia
Mattern, Vicki
Frost, Patrice
Higgins, Paul
Comuzzie, Anthony
Voruganti, Venkata
Affilliation: Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MA, USA / Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA / Southwest National Primate Research Center, San Antonio, TX, USA.
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA / Department of Radiology, Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, MA, USA.
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Ahmanson-Lovelace Brain Mapping Center, University of California at Los Angeles, Los Angeles, CA, USA / Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
Research Imaging Institute, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Southwest National Primate Research Center, San Antonio, TX, USA / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Fundação Oswaldo Cruz. Instituto de Ciência e Tecnologia em Biomodelos. Rio de Janeiro, RJ, Brasil / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Southwest National Primate Research Center, San Antonio, TX, USA.
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA / Department of Genetics, Texas Biomedical Research Institute, San Antonio, TX, USA.
Department of Nutrition and UNC Nutrition Research Institute, University of North Carolina at Chapel Hill, Kannapolis, NC, USA.
Abstract: Changes in cerebral blood flow (CBF) during a hyperglycemic challenge were mapped, using perfusion-weighted MRI, in a group of non-human primates. Seven female baboons were fasted for 16 h prior to 1-h imaging experiment, performed under general anesthesia, that consisted of a 20-min baseline, followed by a bolus infusion of glucose (500 mg/kg). CBF maps were collected every 7 s and blood glucose and insulin levels were sampled at regular intervals. Blood glucose levels rose from 51.3 ± 10.9 to 203.9 ± 38.9 mg/dL and declined to 133.4 ± 22.0 mg/dL, at the end of the experiment. Regional CBF changes consisted of four clusters: cerebral cortex, thalamus, hypothalamus, and mesencephalon. Increases in the hypothalamic blood flow occurred concurrently with the regulatory response to systemic glucose change, whereas CBF declined for other clusters. The return to baseline of hypothalamic blood flow was observed while CBF was still increasing in other brain regions. The spatial pattern of extra-hypothalamic CBF changes was correlated with the patterns of several cerebral networks including the default mode network. These findings suggest that hypothalamic blood flow response to systemic glucose levels can potentially be explained by regulatory activity. The response of extra-hypothalamic clusters followed a different time course and its spatial pattern resembled that of the default-mode network.
Keywords: Hyperglycemic Challenge
Cerebral Blood Flow
Perfusion Imaging
Resting State Network
Default State Network
Arterial Spin Labeling
keywords: Desafio Hiperglicêmico
Fluxo Sanguíneo Cerebral
Imagem de Perfusão
Rede de Estado de Repouso
Rede de Estado Padrão
Rotulagem da Rotação Arterial
Issue Date: 2017
Publisher: Frontiers Media
Citation: KOCHUNOV, Peter et al. Changes in Cerebral Blood Flow during an Alteration in Glycemic State in a Large Non-human Primate (Papio hamadryas sp.). Frontiers in Neuroscience. v. 11, p. 1-12, fev. 2017.
DOI: 10.3389/fnins.2017.00049
ISSN: 1662-4548
Copyright: open access
Appears in Collections:ICTB - Artigos de Periódicos

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