Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/30966

Type
Article
Copyright
Restricted access
Embargo date
2030-01-01
Collections
Share

Statistics
Metadata
Show full item record

FREQUENCY OF VAL1016ILE MUTATION IN THE VOLTAGE-GATED SODIUM CHANNEL GENE OF AEDES AEGYPTI BRAZILIAN POPULATIONS
Martins, Ademir Jesus et al. | Date Issued: 2009
Author
Martins, Ademir Jesus
Lima, José Bento Pereira
Peixoto, Alexandre Afranio
Valle, Denise
Affilliation
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Fisiologia e Controle de Artrópodes Vetores. Rio de Janeiro, RJ, Brasil / Instituto de Biologia do Exército. Rio de Janeiro, RJ, Brasil.
Abstract
One of the major insect pyrethroid resistance mechanisms affects its target site, the voltage-gated sodium channel (Na(v)). In Aedes aegypti, the Val1016Ile substitution of the AaNa(v) gene is associated to resistance in several Latin American countries. Genotyping of susceptible and resistant mosquitoes from seven Brazilian localities detected the 1016Ile mutation in five populations with a higher frequency of this substitution in resistant specimens in all cases. Furthermore, analysis of nine additional field populations revealed that five also presented the 1016Ile mutation. Our data suggest a recent dissemination and involvement of this substitution with pyrethroid resistance in Brazil.
Keywords in Portuguese
Resistência a piretróide
Gene do canal de sódio
Mutação kdr
Brasil
 
Keywords
Pyrethroid resistance
Kdr mutation
Sodium channel gene
Brazil
 
Publisher
Wiley 12 Months
Citation
MARTINS, Ademir Jesus et al. Frequency of Val1016Ile mutation in the voltage-gated sodium channel gene of Aedes aegypti Brazilian populations. Tropical Medicine and International Health, v. 14, n. 11, p. 1351-1355, Nov. 2009.
DOI
10.1111/j.1365-3156.2009.02378.x
ISSN
1360-2276