Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31040
Title: Antimicrobial and antileishmanial activity of essential oil from the leaves of Annona foetida (ANNONACEAE)
Authors: Costa, Emmanoel Vilaça
Pinheiro, Maria Lúcia Belém
Silva, Jefferson Rocha de Andrade
Maia, Beatriz Helena Lameiro de Noronha Sales
Duarte, Marta Cristina Teixeira
Amaral, Ana Cláudia Fernandes
Machado, Gérzia Maria de Carvalho
Leon, Leonor Laura
Affilliation: Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.
Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.
Universidade Federal do Amazonas. Departamento de Química. Manaus, AM, Brasil.
Universidade Federal do Paraná. Departamento de Química. Curitiba, PR, Brasil.
Universidade Estadual de Campinas. Centro Pluridisciplinar de Pesquisas Químicas, Biológicas e Agrícolas. Campinas, SP, Brasil.
Fundação Oswaldo Cruz. Farmanguinhos. Departamento de Produtos Naturais. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Imunologia. Rio de Janeiro, RJ, Brasil.
Abstract: The essential oil from leaves of Annona foetida obtained by hydrodistillation was analyzed by GC/FID and GC/MS. The results showed that the major constituents were bicyclogermacrene (35.12%), (E)-caryophyllene (14.19%) and α-copaene (8.19%). The antimicrobial and antileishmanial activities were investigated. The oil showed potent antimicrobial activity against Candida albicans and Rhodococcus equi. The oil also showed significant antileishmanial activity, giving the best results against Leishmania guyanensis. A preliminary cytotoxicity assay for this oil was carried out on hamster and mice (Balb/c) peritoneal macrophages. The results obtained were similar to pentamidine and considered not to be cytotoxic to macrophages.
Keywords: Annona foetida
Antimicrobial and antileishmanial activities
Essential oil composition
keywords: Annona foetida
Composição de óleo essencial
Atividades antimicrobiana e antileishmanial
Issue Date: 2009
Publisher: Sociedade Brasileira de Química
Citation: COSTA, Emmanoel Vilaça et al. Antimicrobial and Antileishmanial acvtivity of essential oil from the leaves of Annona foetida. Qumi. Nova, v. 32, n. 1, p. 78-81, 2009.
ISSN: 0100-4042
Copyright: open access
Appears in Collections:Farmanguinhos - Artigos de Periódicos
IOC - Artigos de Periódicos

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