Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/31118
Title: An autochthonous case of hepatitis C virus genotype 5a in Brazil: phylogenetic analysis
Authors: Ribeiro, Luciano C.
Souto, Francisco Jose Dutra
Espírito-Santo, Márcia P. do
Oliveira, Rodrigo G.
Lampe, Elisabeth
Affilliation: Universidade Federal de Mato Grosso. Faculdade de Ciências Médicas. Departamento de Clínica Médica. Cuiabá, MT, Brasil.
Universidade Federal de Mato Grosso. Faculdade de Ciências Médicas. Departamento de Clínica Médica. Cuiabá, MT, Brasil.
Technical University of Denmark. Center for Biological Sequence Analysis. Lingby, Denmark.
Technical University of Denmark. Center for Biological Sequence Analysis. Lingby, Denmark.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Virologia. Laboratório de Hepatites Virais. Rio de Janeiro, RJ, Brasil.
Abstract: Genotype 5 of hepatitis C virus (HCV) has been rarely identified in South America. A female of African descent who never left Brazil was found to be infected by this genotype in Mato Grosso state, Central Brazil. The patient denied drug injections and revealed that she had received blood transfusions several years before. One of her blood donors was identified and tested negative for anti-HCV and HCV RNA, as were her husband and offspring. Phylogenetic analysis of the E1 and NS5B regions confirmed that this HCV strain belonged to genotype 5a. However, the E1 region analysis indicates that our strain is not closely related to any sequences of genotype 5a from other geographical areas, diverging from the African and European subclades known so far. These data suggest that genotype 5a HCV might have been circulating at a low level in Brazil longer than previously supposed.
Keywords: Autochthonous case
Hepatitis C virus
Genotype 5a
Brazil
Phylogenetic analysis
keywords: Vírus da Hepatite C
Brasil
Caso autóctone
Genótipo 5a
Análise filogenética
Issue Date: 2009
Publisher: Springer-Verlag
Citation: RIBEIRO, Luciano C. et al. An autochthonous case of hepatitis C virus genotype 5a in Brazil: phylogenetic analysis. Archives of Virology, v. 154, p. 665-670, Mar. 2009.
DOI: 10.1007/s00705-008-0279-3
ISSN: 0304-8608
Copyright: restricted access
Appears in Collections:IOC - Artigos de Periódicos

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