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2022-01-01
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- INI - Artigos de Periódicos [3650]
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CLINICAL AND LABORATORY SIGNS AS DENGUE MARKERS DURING AN OUTBREAK IN RIO DE JANEIRO
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Abstract
Background: One of the main challenges for clinical research in dengue is the low validity of clinical diagnosis. Objective: To analyze clinical and laboratory data as predicitve factors of dengue diagnosis at Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, during
the 2001–2002 dengue outbreak in Rio de Janeiro. Methods: Cross sectional study comparing clinical laboratory data collected from the National Information System for Compulsory Notification Diseases (SINAN) in two serologically confirmed groups: dengue D (N = 453)
and non-dengue ND (N = 80). Results: Fever, exanthema, itching, mean platelet count < 150,000, WBC count < 4,000 and absence of vomiting
and of abdominal pain help to distinguish D from ND groups. When considered individually, these signs and symptoms enhance diagnostic sensitivity and, when used in combination, improve specificity. Conclusion: A combination of symptoms not necessarily considered indicative of dengue diagnosis could improve surveillance and medical decision-making in simple clinical settings.
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