| Author | Leite, Ana C. C. | pt_BR |
| Author | Mendonça, Gulnar A. S. | pt_BR |
| Author | Serpa, Maria José Andrada | pt_BR |
| Author | Nascimento, Osvaldo J. M. | pt_BR |
| Author | Araújo, Abelardo Q.-C. | pt_BR |
| Access date | 2019-06-11T13:02:32Z | |
| Available date | 2019-06-11T13:02:32Z | |
| Document date | 2003 | |
| Citation | LEITE, Ana C.C et al. Neurological manifestations in HTLV-I infected blood donors. Journal of the Neurological Science, v. 214, n. 1-2, p. 49-56, 2003. | pt_BR |
| ISSN | 0022-510X | |
| URI | https://www.arca.fiocruz.br/handle/icict/33453 | |
| Language | por | pt_BR |
| Rights | restricted access | pt_BR |
| Title | Neurological manifestations in HTLV-I infected blood donors | pt_BR |
| Type | Article | |
| DOI | 10.1016/S0022-510X(03)00179-5 | pt_BR |
| Abstract | The human T-cell lymphotropic virus type 1 (HTLV-I) causes a neurological disease known as HTLV-I-associated myelopathy/tropicalspastic paraparesis (HAM/TSP) in a minority of infected individuals. Although other neurological outcomes have been described theirprevalence is presently unknown. To evaluate the frequency and characteristics of neurological involvement in a population of HTLV-I-infected blood donors we investigated 196 HTLV-I positive and 196 negative blood donors from a blood center of Rio de Janeiro, Brazil.Individuals with abnormalities at the neurological examination were examined by three neurologists, and when pertinent, additionalneurological investigations were performed. Descriptive analysis, Student’st-test andv2test were employed for statistical analysis.Neurological abnormalities were found in 71 (36.2%) of the HTLV-I positive blood donors and in only 29 (14.8%) of the HTLV-I negativedonors (OR = 2.54, 95% CI = 1.67–3.59,p=0.000002). Cases of myelopathy, motor neuron disease and myopathy were only found in theHTLV-I positive group. In addition, peripheral neuropathy (PN) was significantly more frequent in the positive group (p= 0.015). Insummary, our data suggest that HTLV-I-infected individuals exhibit a wide variety of neurological manifestations apart from the classicalpicture of HAM/TSP. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil / Rio de Janeiro’s State Institute of Hematology Arthur Siqueira Cavalcanti. Rio de Janeiro, RJ, Brazil. | |
| Affilliation | Rio de Janeiro State University. Department of Epidemiology. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Affilliation | The Fluminense Federal University. Service of Neurology. Niterói, RJ, Brasil. | |
| Affilliation | Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil. | |
| Subject | HTLV-I | |
| Subject | Blood donors | |
| Subject | HTLV-I-associated myelopathy | |
| Subject | Peripheral neuropath | |
| Subject | Myopathy | |
| Subject | Motor neuron disease | |
