Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/33453
Title: Neurological manifestations in HTLV-I infected blood donors
Authors: Leite, Ana C. C.
Mendonça, Gulnar A. S.
Serpa, Maria José Andrada
Nascimento, Osvaldo J. M.
Araújo, Abelardo Q.-C.
Affilliation: Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil / Rio de Janeiro’s State Institute of Hematology Arthur Siqueira Cavalcanti. Rio de Janeiro, RJ, Brazil.
Rio de Janeiro State University. Department of Epidemiology. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
The Fluminense Federal University. Service of Neurology. Niterói, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de pesquisa Clínica Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Abstract: The human T-cell lymphotropic virus type 1 (HTLV-I) causes a neurological disease known as HTLV-I-associated myelopathy/tropicalspastic paraparesis (HAM/TSP) in a minority of infected individuals. Although other neurological outcomes have been described theirprevalence is presently unknown. To evaluate the frequency and characteristics of neurological involvement in a population of HTLV-I-infected blood donors we investigated 196 HTLV-I positive and 196 negative blood donors from a blood center of Rio de Janeiro, Brazil.Individuals with abnormalities at the neurological examination were examined by three neurologists, and when pertinent, additionalneurological investigations were performed. Descriptive analysis, Student’st-test andv2test were employed for statistical analysis.Neurological abnormalities were found in 71 (36.2%) of the HTLV-I positive blood donors and in only 29 (14.8%) of the HTLV-I negativedonors (OR = 2.54, 95% CI = 1.67–3.59,p=0.000002). Cases of myelopathy, motor neuron disease and myopathy were only found in theHTLV-I positive group. In addition, peripheral neuropathy (PN) was significantly more frequent in the positive group (p= 0.015). Insummary, our data suggest that HTLV-I-infected individuals exhibit a wide variety of neurological manifestations apart from the classicalpicture of HAM/TSP.
Keywords: HTLV-I
Blood donors
HTLV-I-associated myelopathy
Peripheral neuropath
Myopathy
Motor neuron disease
Issue Date: 2003
Citation: LEITE, Ana C.C et al. Neurological manifestations in HTLV-I infected blood donors. Journal of the Neurological Science, v. 214, n. 1-2, p. 49-56, 2003.
DOI: 10.1016/S0022-510X(03)00179-5
ISSN: 0022-510X
Copyright: restricted access
Appears in Collections:INI - Artigos de Periódicos

Files in This Item:
File Description SizeFormat 
ve_Amaral_V_etal_INI_2001.pdf122.95 kBAdobe PDFView/Open



FacebookTwitterDeliciousLinkedInGoogle BookmarksBibTex Format mendeley Endnote DiggMySpace

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.