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CIRCULATING LEVELS OF INSULIN-LIKE GROWTH FACTOR-I (IGF-I) CORRELATE WITH DISEASE STATUS IN LEPROSY
Hanseníase
Reações de lepra
Biomarcador
Sistema neuroendócrino
Resposta imune-inflamatória
IGF-1
IGFPB-3
Leprosy reactions
Mycobacterium leprae
Biomarker
Neuroendocrine system
Immune-inflammatory response
Author
Affilliation
Abstract
Caused by Mycobacterium leprae (ML), leprosy presents a strong immune-inflammatory component, whose status dictates both the clinical form of the disease and the occurrence of reactional episodes. Evidence has shown that, during the immune-inflammatory response to infection, the growth hormone/insulin-like growth factor-I (GH/IGF-I) plays a prominent regulatory role. However, in leprosy, little, if anything, is known about the interaction between the immune and neuroendocrine systems.
Keywords in Portuguese
Mycobacterium lepraeHanseníase
Reações de lepra
Biomarcador
Sistema neuroendócrino
Resposta imune-inflamatória
Keywords
LeprosyIGF-1
IGFPB-3
Leprosy reactions
Mycobacterium leprae
Biomarker
Neuroendocrine system
Immune-inflammatory response
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