Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/34042
Title: Circulating levels of insulin-like growth factor-I (IGF-I) correlate with disease status in leprosy
Authors: Rodrigues, Luciana Silva
Hacker, Mariana Andrea
Illarramendi, Ximena
Pinheiro, Maria Fernanda Miguens Castelar
Nery, José Augusto da Costa
Sarno, Euzenir Nunes
Pessolani, Maria Cristina Vidal
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Ri de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Ri de Janeiro, RJ, Brasil.
Laboratório Sergio Franco. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Ri de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Hanseníase. Ri de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Microbiologia Celular. Rio de Janeiro, RJ, Brasil.
Abstract: Caused by Mycobacterium leprae (ML), leprosy presents a strong immune-inflammatory component, whose status dictates both the clinical form of the disease and the occurrence of reactional episodes. Evidence has shown that, during the immune-inflammatory response to infection, the growth hormone/insulin-like growth factor-I (GH/IGF-I) plays a prominent regulatory role. However, in leprosy, little, if anything, is known about the interaction between the immune and neuroendocrine systems.
Keywords: Leprosy
IGF-1
IGFPB-3
Leprosy reactions
Mycobacterium leprae
Biomarker
Neuroendocrine system
Immune-inflammatory response
keywords: Mycobacterium leprae
Hanseníase
Reações de lepra
Biomarcador
Sistema neuroendócrino
Resposta imune-inflamatória
Issue Date: 2011
Publisher: BMC
Citation: RODRIGUES, Luciana Silva et al. Circulating levels of insulin-like growth factor-I (IGF-I) correlate with disease status in leprosy. BMC Infectious Diseases, v. 11, n. 339, p. 1-8, 2011.
DOI: 10.1186/1471-2334-11-339
ISSN: 1471-2334
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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