Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/34832
Title: Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals
Authors: Noordam, Raymond
Young, William J.
Salman, Reem
Kanters, Jørgen K.
Berg, Marten E.van den
Heemst, Dianavan
Lin, Henry J.
Barreto, Sandhi Maria
Biggs, Mary L.
Biino, Ginevra
Catamo, Eulalia
Munroe, Patricia B.
Warren, Helen R.
Concas, Maria Pina
Ding, Jun
Evans, Daniel S.
Foco, Luisa
Grarup, Niels
Lyytikäinen, Leo-Pekka
Mangino, Massimo
Mei, Hao
Most, Peter J. van der
Müller-Nurasyid, Martina
Nelson, Christopher P.
Qian, Yong
Repetto, Linda
Said, M. Abdullah
Shah, Nabi
Schramm, Katharina
Vidigal, Pedro G.
Yao, Jie
Zilhao, Nuno R.
Brody, Jennifer A.
Braund, Peter S.
Brumat, Marco
Campana, Eric
Christofidou, Paraskevi
Caulfield, Mark J.
Grandi, Alessandro De
Dominiczak, Anna F.
Doney, Alex S.F.
Eiriksdottir, Gudny
Ellervik, Christina
Giatti, Luana
Gögele, Martin
Graff, Claus
Guo, Xiuqing
Harst, Pim van der
Joshi, Peter K.
Kähönen, Mika
Kestenbaum, Bryan
Costa, Maria Fernanda Furtado Lima
Linneberg, Allan
Maan, Arie C.
Meitinger, Thomas
Padmanabhan, Sandosh
Pattaro, Cristian
Peters, Annette
Petersmann, Astrid
Sever, Peter
Sinner, Mortiz F.
Shen, Xia
Stanton, Alice
Strauch, Konstantin
Soliman, Elsayed Z.
Tarasov, Kirill V.
Taylor, Kent D.
Thio, Chris H.L.
Uitterlinden, André G.
Vaccargiu, Simona
Waldenberger, Melanie
Robino, Antonietta
Correa, Adolfo
Cucca, Francesco
Cummings, Steven R.
Dörr, Marcus
Girotto, Giorgia
Gudnason, Vilmundur
Hansen, Torben
Heckbert, Susan R.
Juhl, Christian R.
Kääb, Stefan
Lehtimäki, Terho
Liu, Yongmei
Lotufo, Paulo A.
Palmer, Colin N.A.
Pirastu, Mario
Ribeiro, Antonio Luiz P.
Rotter, Jerome I
Samani, Nilesh J.
Snieder, Harold
Spector, Tim D.
Stricker, Bruno H.
Verweij, Niek
Wilson, James F.
Wilson, James G.
Jukema, Wouter
Tinker, Andrew
Newton-Cheh, Christopher H.
Sotoodehnia, Nona
Mook-Kanamori, Dennis O.
Affilliation: Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Barts Heart Centre, St. Bartholomew's Hospital, London, United Kingdom/Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark/Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands.
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California/Division of Medical Genetics, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California/Department of Pediatrics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil.
Cardiovascular Health Research Unit, Department of Medicine, and Department of Biostatistics, University of Washington, Seattle, Washington.
Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy.
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom/ National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, United Kingdom.
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom/ National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, United Kingdom.
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
California Pacific Medical Center Research Institute, San Francisco, California.
Eurac Research, Institute for Biomedicine, affiliated to the University of Lübeck, Bolzano, Italy.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden, the Netherlands/California Pacific Medical Center Research Institute, San Francisco, California.
Department of Data Science, University of Mississippi Medical Center, Jackson, Mississippi.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany/Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany/DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Cardiovascular Research Centre, Glenfield Hospital, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom/National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.
Translational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Centre for Global Health Reasearch, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Department of Cardiology and Thorax Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Division of Molecular and Clinical Medicine, Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom/Department of Pharmacy, COMSATS University Islamabad, Abbottabad, Pakistan.
Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany/Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil/Interfaculty Institute for Genetics and Functional Genomics, University of Greifswald, Greifswald, Germany/German Centre for Cardiovascular Research, partner site Greifswald, Greifswald, Germany.
Institute for Translational Genomics and Population Sciences, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California.
Icelandic Heart Association, Kópavogur, Iceland.
Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington.
Cardiovascular Research Centre, Glenfield Hospital, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom/National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.
Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom.
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom/ National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, United Kingdom.
Eurac Research, Institute for Biomedicine, affiliated to the University of Lübeck, Bolzano, Italy.
Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom.
Division of Molecular and Clinical Medicine, Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.
Icelandic Heart Association, Kópavogur, Iceland.
Department of Production, Research and Innovation, Region Zealand, SorØ, Denmark/Harvard Medical School, Boston, Massachusetts/Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts/Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil.
Eurac Research, Institute for Biomedicine, University of Lübeck, Bolzano, Italy.
Department of Health Science and Technology, Aalborg University, Aalborg, Denmark.
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Centre for Global Health Reasearch, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Centre for Global Health Reasearch, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland.
Department of Clinical Physiology, Tampere University Hospital, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Kidney Research Institute, University of Washington, Seattle, Washington.
Fundação Oswaldo Cruz. Instituto Rene Rachou. Belo Horizonte, MG, Brazil.
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark/ Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Institute of Human Genetics, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany/Institute of Human Genetics, Technische Universität München, Munich, Germany.
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
Eurac Research, Institute for Biomedicine, affiliated to the University of Lübeck, Bolzano, Italy.
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands/Institute of Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany/German Center for Diabetes Research, Neuherberg, Germany.
Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany.
National Heart and Lung Institute, Imperial College London, London, United Kingdom.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany/DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Centre for Global Health Reasearch, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland/ Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden/Biostatistics Group, State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat-sen University, Guangzhou, China.
Molecular and Cellular Therapeutics, Royal College of Surgeons in Ireland, Dublin, Ireland.
Institute of Genetic Epidemiology, Helmholtz Zentrum München—German Research Center for Environmental Health, Neuherberg, Germany/Institute for Medical Information Processing, Biometry, and Epidemiology, Faculty of Medicine, Ludwig Maximilian University of Munich, Munich, Germany.
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina/Epidemiological Cardiology Research Center, Wake Forest School of Medicine, Winston Salem, North Carolina/Department of Internal Medicine, Cardiology Section, Wake Forest School of Medicine, Winston Salem, North Carolina.
Laboratory of Cardiovascular Science, National Institute on Aging, National Institutes of Health, Baltimore, Maryland.
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom/Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Human Genotyping Facility, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany/ Centre for Global Health Reasearch, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland/ Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts.
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy.
Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi.
Department of Biomedical Sciences, University of Sassari, Sassari, Italy.
California Pacific Medical Center Research Institute, San Francisco, California.
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Institute for Maternal and Child Health, IRCCS Burlo Garofolo, Trieste, Italy/Department of Medicine, Surgery and Health Sciences, University of Trieste, Trieste, Italy.
Icelandic Heart Association, Kópavogur, Iceland/Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Cardiovascular Health Research Unit and the Department of Epidemiology, University of Washington, Seattle, Washington.
Laboratory of Experimental Cardiology, Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark.
Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany/X DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Munich, Germany.
Department of Clinical Chemistry, Fimlab Laboratories, Finnish Cardiovascular Research Center Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University, Winston-Salem, North Carolina.
Medical School and Center for Clinical and Epidemiologic Research, University of São Paulo, São Paulo, Brazil.
Division of Molecular and Clinical Medicine, Pat Macpherson Centre for Pharmacogenetics and Pharmacogenomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom.
Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil.
Division of Genomic Outcomes, Department of Pediatrics, Harbor-UCLA Medical Center, Torrance, California.
Cardiovascular Research Centre, Glenfield Hospital, Department of Cardiovascular Sciences, University of Leicester, Leicester, United Kingdom/National Institute for Health Research Leicester Biomedical Research Centre, Glenfield Hospital, Leicester, United Kingdom.
Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
Department of Twin Research and Genetic Epidemiology, King’s College London, London, United Kingdom.
Department of Epidemiology, Erasmus University Medical Center Rotterdam, Rotterdam, the Netherlands.
Department of Cardiology and Thorax Surgery, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
Centre for Global Health Reasearch, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland/MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, United Kingdom.
Universidade Federal de Minas Gerais. Faculdade de Medicina. Hospital das Clínicas. Belo Horizonte, MG, Brazil/Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi.
Department of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.
Clinical Pharmacology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom/National Institute for Health Research Barts Cardiovascular Biomedical Research Centre, Queen Mary University of London, London, United Kingdom.
Cardiovascular Research Center, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts/Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts/Center for Genomic Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts.
Cardiovascular Health Research Unit, Division of Cardiology, Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington.
Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands/Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands.
Abstract: BACKGROUND: Subclinical changes on the electrocardiogram are risk factors for cardiovascular mortality. Recognition and knowledge of electrolyte associations in cardiac electrophysiology are based on only in vitro models and observations in patients with severe medical conditions. OBJECTIVES: This study sought to investigate associations between serum electrolyte concentrations and changes in cardiac electrophysiology in the general population. METHODS: Summary results collected from 153,014 individuals (54.4% women; mean age 55.1 ± 12.1 years) from 33 studies (of 5 ancestries) were meta-analyzed. Linear regression analyses examining associations between electrolyte concentrations (mmol/l of calcium, potassium, sodium, and magnesium), and electrocardiographic intervals (RR, QT, QRS, JT, and PR intervals) were performed. The study adjusted for potential confounders and also stratified by ancestry, sex, and use of antihypertensive drugs. RESULTS: Lower calcium was associated with longer QT intervals (-11.5 ms; 99.75% confidence interval [CI]: -13.7 to -9.3) and JT duration, with sex-specific effects. In contrast, higher magnesium was associated with longer QT intervals (7.2 ms; 99.75% CI: 1.3 to 13.1) and JT. Lower potassium was associated with longer QT intervals (-2.8 ms; 99.75% CI: -3.5 to -2.0), JT, QRS, and PR durations, but all potassium associations were driven by use of antihypertensive drugs. No physiologically relevant associations were observed for sodium or RR intervals. CONCLUSIONS: The study identified physiologically relevant associations between electrolytes and electrocardiographic intervals in a large-scale analysis combining cohorts from different settings. The results provide insights for further cardiac electrophysiology research and could potentially influence clinical practice, especially the association between calcium and QT duration, by which calcium levels at the bottom 2% of the population distribution led to clinically relevant QT prolongation by >5 ms.
Keywords: Cohort studies
Electrocardiographic intervals
Electrolytes
Epidemiology
Meta-analysis
Issue Date: 2019
Publisher: American College of Cardiology
Citation: NOORDAM, Raymond et al. Effects of Calcium, Magnesium, and Potassium Concentrations on Ventricular Repolarization in Unselected Individuals. Journal of the American College of Cardiology, v. 73, n. 24, p. 3118-3131, 2019.
DOI: 10.1016/j.jacc.2019.03.519
ISSN: 0735-1097
Copyright: restricted access
Appears in Collections:MG - IRR - Artigos de Periódicos

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