Trypanosoma cruzi in a caviomorph rodent: parasitological and pathological features of the experimental infection of Trichomys apereoides (Rodentia, Echimyidae)

Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil / Central University of Venezuela. Science Faculty. Institute of Tropical Zoology. Caracas, Venezuela.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.
Central University of Venezuela. Medicine Faculty. Nutrition School. Caracas, Venezuela.
Fundação Oswaldo Cruz. Instituto Nacional de Infectologia Evandro Chagas. Rio de Janeiro, RJ, Brasil.
Central University of Venezuela. Faculty Medicine. Tropical Medicine Institute. Caracas, Venezuela.
Central University of Venezuela. Science Faculty. Institute of Tropical Zoology. Caracas, Venezuela.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Protozoologia. Laboratório de Biologia de Tripanossomatídeos. Rio de Janeiro, RJ, Brasil.

Abstract

To understand the interaction of Trypanosoma cruzi with caviomorph rodents, which supposedly have an ancient co-evolutionary history with this parasite, experimental infection of laboratory reared Trichomys apereoides with several isolates of both genotypes of the parasite was studied. Parasitemia, pattern of hematic cells, specific humoral immune response, histopathological features and parasite clearance were appraised. T. apereoides maintained stable infections independent of the T. cruzi genotype as demonstrated by positive PCR results in analyses of several tissues after a 5 months follow-up. The acute phase was characterized by abundant and disseminated presence of amastigotes, vacuolization and/or myocytolysis. Lymphocytosis was a common feature. The chronic phase was characterized mainly by lymphomacroeosinophilic infiltrates independent of the inoculated T. cruzi isolate. T. cruzi of different genotypes did not show any tissular preference in T. apereoides.

Keywords in Portuguese

Trypanosoma cruzi
Doença de Chagas
Histopatologia
Trichomys apereoides
Infecção

Keywords

Trypanosoma cruzi
Chagas Disease
Histopathology
Trichomys apereoides
Infection

Publisher

Elsevier 12 Months

Citation

HERRERA, Leide et al. Trypanosoma cruzi in a caviomorph rodent: parasitological and pathological features of the experimental infection of Trichomys apereodes (Rodentia, Echimyidae). Experimental Parasitology, v.107, p. 78-88, 2004.

DOI

10.1016/j.exppara.2004.04.008

ISSN

0014-4894

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/35813

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Copyright

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Embargo date

2025-01-01

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