Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/3783
Title: Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis
Authors: Pereira, Martha Maria
Silva, João José Pereira da
Pinto, Marcelo Alves
Silva, Mauro França da
Machado, Marcelo Pelajo
Lenzi, Henrique Leonel
Marchevsky, Renato Sergio
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Universidade Federal Fluminense. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto de Tecnologia em Imunobiológicos. Rio de Janeiro, RJ, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Rio de Janeiro, RJ, Brasil.
Abstract: Experimental infection of marmoset monkeys (Callithrix jacchus) with Leptospira interrogans serovar Copenhageni showed microscopic patterns of tissue reactions comparable to those seen in the severe forms of human leptospirosis, including intra-alveolar hemorrhage. The most impressive microscopic changes were seen in the lung and kidney of animals killed at days 6 and 12 after inoculation. There were extensive and irregular areas of hemorrhage predominating around main bronchial branches or diffusely spread to the pulmonary parenchyma, as well as severe tubulointerstitial nephritis. Antibody response detected by the microscopic agglutination test was quantitatively similar to those seen in humans and paralleled severity of tissue lesions. The distribution of leptospires or antigenic debris in infected tissues was observed by immunofluorescence and confocal laser scanning microscopy. Large numbers of typical leptospires were seen in the lumen of proximal renal tubules. Positive reactions showing antigenic debris were closely associated with sites of tissue damage.
Keywords: Hemorrhage
Etiology
Leptospirosis
Immunology
Pathology
Animals
Haplorhini
DeCS: Haplorrinos
Animais
Hemorragia
Leptospirose
Imunologia
Patologia
Etiologia
Issue Date: 2005
Publisher: American Society of Tropical Medicine and Hygiene
Citation: PEREIRA, M. M. et al. Experimental leptospirosis in marmoset monkeys (Callithrix jacchus): a new model for studies of severe pulmonary leptospirosis. American Journal of Tropical Medicine and Hygiene, v.72, n.1, p. 13-20, 2005.
Description: Acknowledgments: We thank Antonio José Alves, Emilson Domingues da Silva, José Mariano da Silva, José Wanderley Pissurno, and Luzia de Fatima Caputo for their excellent and dedicated technical support. We also thank the Primate Information Center, University of Washington (Seattle, WA) for providing bibliographic information about leptospirosis in primates.
ISSN: 0002-9637
Copyright: open access
Appears in Collections:Biomanguinhos - Artigos de Periódicos
IOC - Artigos de Periódicos

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