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2025-01-01
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BOOSTING OF CELLULAR IMMUNITY AGAINST MYCOBACTERIUM TUBERCULOSIS AND MODULATION OF SKIN CYTOKINE RESPONSES IN HEALTHY HUMAN VOLUNTEERS BY MYCOBACTERIUM BOVIS BCG SUBSTRAIN MOREAU RIO DE JANEIRO ORAL VACCINE
Cosgrove, Catherine A. et al. | Date Issued: 2006
Author
Cosgrove, Catherine A.
Castello Branco, Luiz R. R.
Hussell, Tracy
Sexton, Amy
Giemza, Rafaela
Phillips, Richard
Williams, Andrew
Griffin, George E.
Dougan, Gordon
Lewis, David J. M.
Affilliation
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil.
Imperial College. Center for Molecular Microbiology and Immunology. London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Imperial College. Center for Molecular Microbiology and Immunology. London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Sanger Institute, Cambridge, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Abstract
Oral immunization of healthy adults with 10(7) CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
Keywords in Portuguese
Imunidade celular
Mycobacterium tuberculosis
Mycobacterium bovis
Vacina oral
BCG
Citocinas cutâneas
Voluntários humanos saudáveis
 
Keywords
Mycobacterium tuberculosis
Cellular Immunity
Mycobacterium bovis BCG
Oral vaccine
Skin Cytokine
Healthy Human Volunteers
 
Publisher
American Society for Microbiology
Citation
COSGROVE, Catherine A. et al. Boosting of Cellular Immunity against Mycobacterium tuberculosis and Modulation of Skin Cytokine Responses in Healthy Human Volunteers by Mycobacterium bovis BCG Substrain Moreau Rio de Janeiro Oral Vaccine. Infection and Immunity, v. 74, n. 4, p. 2449-2452, Apr. 2006.
DOI
10.1128/IAI.74.4.2449-2452.2006
ISSN
0019-9567