Please use this identifier to cite or link to this item:
https://www.arca.fiocruz.br/handle/icict/38970
Type
ArticleCopyright
Restricted access
Embargo date
2025-01-01
Sustainable Development Goals
03 Saúde e Bem-EstarCollections
- IOC - Artigos de Periódicos [12973]
Metadata
Show full item record
BOOSTING OF CELLULAR IMMUNITY AGAINST MYCOBACTERIUM TUBERCULOSIS AND MODULATION OF SKIN CYTOKINE RESPONSES IN HEALTHY HUMAN VOLUNTEERS BY MYCOBACTERIUM BOVIS BCG SUBSTRAIN MOREAU RIO DE JANEIRO ORAL VACCINE
Mycobacterium tuberculosis
Mycobacterium bovis
Vacina oral
BCG
Citocinas cutâneas
Voluntários humanos saudáveis
Cellular Immunity
Mycobacterium bovis BCG
Oral vaccine
Skin Cytokine
Healthy Human Volunteers
Author
Affilliation
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil.
Imperial College. Center for Molecular Microbiology and Immunology. London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Imperial College. Center for Molecular Microbiology and Immunology. London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Sanger Institute, Cambridge, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Fundação Ataulpho de Paiva. Rio de Janeiro, RJ, Brasil.
Imperial College. Center for Molecular Microbiology and Immunology. London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Imperial College. Center for Molecular Microbiology and Immunology. London, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Sanger Institute, Cambridge, United Kingdom.
St George’s Vaccine Institute. St George’s Hospital Medical School.London, United Kingdom.
Abstract
Oral immunization of healthy adults with 10(7) CFU BCG Moreau Rio de Janeiro was well tolerated and significantly boosted gamma interferon responses to purified protein derivative, Ag85, and MPB70 from previous childhood intradermal BCG immunization. Oral BCG offers the possibility of a needle-free tuberculosis vaccine and of boosting the protective immunity from intradermal tuberculosis vaccines.
Keywords in Portuguese
Imunidade celularMycobacterium tuberculosis
Mycobacterium bovis
Vacina oral
BCG
Citocinas cutâneas
Voluntários humanos saudáveis
Keywords
Mycobacterium tuberculosisCellular Immunity
Mycobacterium bovis BCG
Oral vaccine
Skin Cytokine
Healthy Human Volunteers
Share