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DC-SIGN ASSOCIATION WITH THE TH2 ENVIRONMENT OF LEPROMATOUS LESIONS: CAUSE OR EFFECT?
Soilleux, E. J. et al. | Date Issued: 2006
Author
Soilleux, E. J.
Sarno, E. N.
Hernandez, M. O.
Moseley, E.
Horsley, J.
Lopes, U. G.
Goddard, M. J.
Vowler, S. L.
Coleman, N.
Shattock, R. J.
Sampaio, E. P.
Affilliation
Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK / Medical Research Council Cancer Cell Unit. Hutchison/MRC Research Centre. Cambridge, UK / University of Oxford. Nuffield Department of Clinical Laboratory Sciences. Oxford, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK.
Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK.
Universidade Federal do Rio de Janeiro. Instituto de Biofísica Carlos Chagas Filho. Laboratório de Parasitologia Molecular. Rio de Janeiro, RJ, Brasil.
Papworth Hospital. Department of Histopathology. Papworth Everard, Cambridge, UK.
University of Cambridge Forvie Site. Department of Public Health and Primary Care. Centre for Applied Medical Statistics. Cambridge, UK.
Medical Research Council Cancer Cell Unit. Hutchison/MRC Research Centre. Cambridge, UK.
St. George’s Hospital Medical School. Department of Cellular and Molecular Medicine, Infectious Diseases. London, UK.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Medicina Tropical. Laboratório de Hanseníase. Rio de Janeiro, RJ, Brasil.
Abstract
The clinical spectrum of leprosy is related to patients' immune responses. Non-responsiveness towards Mycobacterium leprae (ML) seems to correlate with a Th2 cytokine profile. The reason for such a polarized immune response remains unclear. The C-type lectin, DC-SIGN, expressed by subsets of dendritic cells (DCs) and macrophages, has previously been associated with Th2 responses. Here we show abundant DC-SIGN expression in lepromatous but not borderline tuberculoid leprosy, in both HIV-positive and HIV-negative patients. Moreover, we demonstrate that DC-SIGN can act as an entry receptor for ML, as it does for M. tuberculosis, through the cell wall component lipoarabinomannan. DC-SIGN is expressed on virtually all ML-containing cells, providing further evidence for its role as a receptor. DC-SIGN may therefore be induced on macrophages in lepromatous leprosy and may then contribute to mycobacterial entry into these cells.
Keywords in Portuguese
Mycobacterium leprae
Hanseníase
Macrófagos
 
Keywords
DC-SIGN
Macrophage
ManLAM
Leprosy
M. leprae
 
Publisher
Wiley
Citation
SOILLEUX, EJ et al. DC-SIGN association with the Th2 environment of lepromatous lesions: cause or effect? Journal of Pathology, v. 209, p. 182-189, Mar. 2006.
DOI
10.1002/path.1972
ISSN
0022-3417