Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4069
Title: Extramedullary hematopoiesis in murine schistosomiasis mansoni
Authors: Lenzi, Henrique Leonel
Lenzi, Jane A.
Rosman, F. C.
Machado, Marcelo Pelajo
Mota, M.
Panasco, Monica de Souza
Oliveira, Denise N.
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: During Schistosoma mansoni infection, there is morphological evidence of involvement of various hematopoietic growth factors, which cause eosinophil, neutrophil, megakaryocytic and erythroid extramedullary foci in the liver, lymph nodes and omental and mesenteric milky spots. While the eosinophil metaplasia in the periphery of hepatic granulomas roughly reproduced the intensity of the medullary eosinopoiesis, the neutrophil metaplasia, on the contrary, was more intense during the period of neutrophil depression in the bone marrow. This fact suggests that extramedullary hematopoietic foci are locally regulated, and amplify and/or compensate the systemic hematopoietic response during the infection.
Keywords: Cosinophil
neutrophil
Megakaryocyte
Hematopoiesis
Schistosoma mansoni
Lymph nodes
Milky spots
DeCS: Schistosoma mansoni
Infecção
Megacariócitos
Hematopoese
Linfonodos
Issue Date: 1995
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: LENZI H. L. et al. Extramedullary hematopoiesis in murine schistosomiasis mansoni. Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.90, n.2, p.169-177. Apr 1995.
DOI: http://dx.doi.org/10.1590/S0074-02761995000200008
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IOC - Artigos de Periódicos

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