Please use this identifier to cite or link to this item:
Type
ArticleCopyright
Open access
Collections
- IOC - Artigos de Periódicos [12337]
Metadata
Show full item record
EXTRAMEDULLARY HEMATOPOIESIS IN MURINE SCHISTOSOMIASIS MANSONI
neutrophil
Megakaryocyte
Hematopoiesis
Schistosoma mansoni
Lymph nodes
Milky spots
Author
Affilliation
Abstract
During Schistosoma mansoni infection, there is morphological evidence of involvement of various hematopoietic growth factors, which cause eosinophil, neutrophil, megakaryocytic and erythroid extramedullary foci in the liver, lymph nodes and omental and mesenteric milky spots. While the eosinophil metaplasia in the periphery of hepatic granulomas roughly reproduced the intensity of the medullary eosinopoiesis, the neutrophil metaplasia, on the contrary, was more intense during the period of neutrophil depression in the bone marrow. This fact suggests that extramedullary hematopoietic foci are locally regulated, and amplify and/or compensate the systemic hematopoietic response during the infection.
Keywords
Cosinophilneutrophil
Megakaryocyte
Hematopoiesis
Schistosoma mansoni
Lymph nodes
Milky spots
Share