Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/4100
Title: Effects of Schistosomal Mansoni Infection on Calomys callosus Coelom-associated Lymphomyeloid Tissue (Milky Spots)
Authors: Lenzi, Jane A.
Machado, Marcelo Pelajo
Mota, Ester Maria
Oliveira, Denise N.
Panasco, Monica de Souza
Andrade, Zilton de Araújo
Lenzi, Henrique Leonel
Affilliation: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz, Salvador, BA, Brasil
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Departamento de Patologia. Rio de Janeiro, RJ, Brasil.
Abstract: Calomys callosus Rengger, 1830 (Rodentia: Cricetidae) is a mouse-like South American wild rodent, which is permissive to Schistosoma mansoni infection. In this paper we studied the effect of schistosomal infection in C. callosus mesenteric and omental milky spots (MS), subsidiary foci of coelom-associated lymphomyeloid tissue (CALT), during the acute, transitional (acute to chronic), and chronic phases of the infection. MS were morphologically analyzed by histological methods, using brigthfield and confocal laser scanning microscopies. The MS of infected animals were mainly of lymphomyelocytic (42 to 90 days) and lymphoplasmacytic (160 days of infection) types and showed frequent presence of lymphoid follicles with germinal centers, plasmacytogenesis and plasmacytosis, mastocytosis, megakaryopoiesis, erythropoiesis and less pronounced eosinopoiesis. These results indicate that MS are a preferential site of germinal-center-dependent and independent plasmacytogenesis, and a bone marrow-like organ, committed with various cellular lineages. The consequence of C. callosus MS reactivity for schistosomal infection is still unknown and is under investigation.
Keywords: Calomys callosus
coelom-associated lymphomyeloid tissue (CALT)
Schistosoma mansoni
Milky spots
Omentum
Laser confocal microscopy
DeCS: Schistosoma mansoni
Omento
Tecido linfóide
Patologia
Issue Date: 1998
Publisher: Fundação Oswaldo Cruz. Instituto Oswaldo Cruz
Citation: LENZI, Jane A. et al. Effects of Schistosomal mansoni infection on Calomys callosus coelom-associated lymphomyeloid tissue (milky spots). Memórias do Instituto Oswaldo Cruz, Rio de Janeiro, v.93, sup.1, p.13-23, 1998.
Description: Acknowledgemetns to A. L. de Amorim, FF Cruz, ID Pedro and LFG Caputo for their technical assistance.
ISSN: 0074-0276
Copyright: open access
Appears in Collections:IGM - Artigos de Periódicos
IOC - Artigos de Periódicos



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