Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus

Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil.
Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil.
Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Flavivírus. Rio de Janeiro, RJ, Brasil.
Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil.
Universidade de São Paulo. Instituto de Física de São Carlos. São Carlos, SP, Brasil.

Abstract

The Yellow Fever virus (YFV) is transmitted by mosquitos and causes an infection with symptoms including fever, headaches and nausea. In 20–50% of the cases, the disease may evolve to a visceral stage, reaching high mortality rates. YFV NS2B-NS3 protease has been identified as an important drug target

Keywords in Portuguese

Víirus da Febre Amarela
Flavivírus
Brasil
Protease
NS3
NS2B

Keywords

Yellow fever virus
Flavivirus
Potease
NS3
NS2B
Brazil

Publisher

Elsevier

Citation

NOSKE, Gabriela Dias et al. Structural characterization and polymorphism analysis of the NS2B-NS3 protease from the 2017 Brazilian circulating strain of Yellow Fever virus. BBA-General Subjects, v.1864, 129521, 11p, Jan. 2020.

DOI

10.1016/j.bbagen.2020.129521

ISSN

0304-4165

Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/41130

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Copyright

Restricted access

Embargo date

2025-01-01

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