Please use this identifier to cite or link to this item: https://www.arca.fiocruz.br/handle/icict/41351
Title: Primary results of clinical trial for uniform multidrug therapy for Leprosy patients in Brazil (U-MDT/CT-BR): reactions frequency in multibacillary patients
Authors: Penna, Maria Lucia Fernandes
Bührer-Sékula, Samira
Pontes, Maria Araci de Andrade
Cruz, Rossilene
Gonçalves, Heitor de Sá
Penna, Gerson Oliveira
Affilliation: Universidade Federal Fluminense. Departamento de Epidemiologia e Bioestatística. Niterói, RJ, Brasil.
Universidade Federal do Goiás. Instituto de Patologia Tropical e Saúde Pública. Goiânia, GO, Brasil.
Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.
Fundação de Dermatologia e Venereologia Tropical Alfredo da Matta. Manaus, AM, Brasil.
Centro de Dermatologia Dona Libânia, Fortaleza, CE, Brasil.
Universidade de Brasília. Faculdade de Medicina. Núcleo de Medicina Tropical. Brasília, DF, Brasil / Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil.
Abstract: Settings: Many believe that the regular treatment for multibacillary (MB) leprosy cases could be shortened. A shorter treatment, allowing for uniform treatment for all cases, makes case classification superfluous and therefore simplifies leprosy control. Objective: To evaluate the association of the treatment duration with the frequency of reactions among MB patients. Methods: An open-label randomised clinical trial to compare the present routine treatment with one lasting six months. Patients were recruited between March 2007 and February 2012. We analysed the frequency of first reaction with the KaplanMeier method and of recurrent reaction with a Poisson regression, using the treatment group and baciloscopic index level (BI) as independent variables. Logistic regression was used to evaluate the statistical association of different reaction types and the treatment group. Results: Among those with BI , 3, we found a statistical significant difference of reaction frequencies between the treatment groups from 6 to 18 months since the beginning of treatment. This difference disappears at 2 years after the start of treatment. Multiple reactions were associated with the treatment group and with BI $ 3. No specific types of reactions were associated with treatment duration. Conclusion: Although this is the first report of U-MDT/CT-BR, the results presented here support the possibility of use of UMDT in the field.
Keywords: Leprosy
Multidrug therapy
Mycobacterium leprae
Leprostatic agents
DeCS: Hanseníase
Hanseníase Multibacilar
Quimioterapia Combinada
Hansenostáticos
Mycobacterium leprae
Doenças Transmissíveis
Prevalência
Resultado do Tratamento
Issue Date: 2012
Publisher: British Leprosy Relief Association
Citation: PENNA, Maria Lucia Fernandes et al. Primary results of clinical trial for uniform multidrug therapy for Leprosy patients in Brazil (U-MDT/CT-BR): reactions frequency in multibacillary patients. Leprosy Review, [London], v. 83, p. 308-319, 2012.
Description: Gerson Oliveira Penna - Autor vinculado à Fiocruz Brasília, mas não consta a informação no documento.
ISSN: 0305-7518
Copyright: restricted access
Appears in Collections:BSB - Artigos de Periódicos

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