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https://www.arca.fiocruz.br/handle/icict/4190
INHIBITION OF MACROPHAGE ACTIVATION AND LIPOPOLYSACCARIDE-INDUCED DEATH BY SECO-STEROIDS PURIFIED FROM PHYSALIS ANGULATA L.
Ativação de Macrófagos/efeitos de drogas
Physalis/química
Fitosteróis/farmacologia
Sobrevivência Celular/efeitos de drogas
Células Cultivadas
Citocinas/sangue
Citocinas/metabolismo
Relação Dose-Resposta a Droga
Antagonistas de Hormônios/farmacologia
Lactonas/farmacologia
Macrófagos Peritoneais/citologia
Camundongos Endogâmicos BALB C
Mifepristona/farmacologia
Oxido Nítrico/sangue
Extratos Vegetais/química
Author
Affilliation
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Fundação Oswaldo Cruz. Farmanguinhos. Rio de Janeiro, RJ, Brasil.
Fundação Oswaldo Cruz. Centro de Pesquisas Gonçalo Moniz. Salvador, BA, Brasil.
Abstract
Physalis angulata L. is an annual herb widely used in popular medicine for the treatment of a variety of pathologies. Here, we tested
immunomodulatory activities of physalins, seco-steroids purified from P. angulata extracts. Addition of physalins B, F or G, but not D, caused
a reduction in nitric oxide production by macrophages stimulated with lipopolysaccaride and interferon-g. In the presence of physalin B,
macrophages stimulated with lipopolysaccaride, alone or in combination with interferon-g, produced lower levels of tumour necrosis factor
(TNF)-a, interleukin-6 and interleukin-12. The inhibitory activity of physalin B, unlike that of dexamethasone, was not reversed by RU486
[(4-dimethylamino) phenyl-17h-hydroxy-17-(1-propynyl)estra-4,9-dien-3-one], an antiglucocorticoid. Physalin B-treated mice had lower
levels of serum TNF-a than control mice after lipopolysaccaride challenge. More importantly, mice injected with physalins B, F or G survived
after a lethal lipopolysaccaride challenge. These results demonstrate that seco-steroids from P. angulata are potent immunomodulatory
substances and act through a mechanism distinct from that of dexamethasone.
DeCS
Lipopolissacarídeos/farmacologiaAtivação de Macrófagos/efeitos de drogas
Physalis/química
Fitosteróis/farmacologia
Sobrevivência Celular/efeitos de drogas
Células Cultivadas
Citocinas/sangue
Citocinas/metabolismo
Relação Dose-Resposta a Droga
Antagonistas de Hormônios/farmacologia
Lactonas/farmacologia
Macrófagos Peritoneais/citologia
Camundongos Endogâmicos BALB C
Mifepristona/farmacologia
Oxido Nítrico/sangue
Extratos Vegetais/química
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