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| Autor | Santiago, Paula Beatriz | |
| Autor | Assumpção, Teresa C. F. | |
| Autor | Araújo, Carla Nunes de | |
| Autor | Bastos, Izabela Marques Dourado | |
| Autor | Neves, David | |
| Autor | Silva, Ionizete Garcia da | |
| Autor | Charneau, Sébastien | |
| Autor | Queiroz, Rayner Myr L. | |
| Autor | Raiol, Tainá | |
| Autor | Oliveira, João Victor de Araújo | |
| Autor | Sousa, Marcelo Valle de | |
| Autor | Calvo, Eric | |
| Autor | Ribeiro, José M. C. | |
| Autor | Santana, Jaime M. | |
| Fecha de acceso | 2020-08-13T12:48:05Z | |
| Fecha de disponibilización | 2020-08-13T12:48:05Z | |
| Fecha de publicación | 2016 | |
| Referencia | SANTIAGO, Paula Beatriz et al. A deep insight into the sialome of Rhodnius neglectus, a vector of Chagas disease. PLOS Neglected Tropical Diseases, [San Francisco], v. 10, n. 4, p.1-25, apr. 2016. | pt_BR |
| ISSN | 1935-2727 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/42742 | |
| Descripción | Tainá Raiol - Fundação Oswaldo Cruz. Fiocruz Brasília. Brasília, DF, Brasil. Documento produzido em parceria ou por autor vinculado em mais de uma unidade da Fiocruz, mas não consta à informação no documento do vinculo com a Fiocruz Brasília. | pt_BR |
| Promoción | CNPq, CAPES, Finep, FAPDF e NIAID. | pt_BR |
| Idioma | eng | pt_BR |
| Editor | Public Library of Science | pt_BR |
| Derechos de autor | open access | pt_BR |
| MeSH | Genomics | pt_BR |
| MeSH | Animals | pt_BR |
| MeSH | Mass Spectrometry | pt_BR |
| MeSH | Molecular Sequence Data | pt_BR |
| MeSH | Peptide Hydrolases | pt_BR |
| MeSH | Proteomics | pt_BR |
| MeSH | Rhodnius | pt_BR |
| MeSH | Saliva | pt_BR |
| MeSH | Salivary Proteins and Peptides | pt_BR |
| MeSH | Sequence Analysis, DNA | pt_BR |
| MeSH | Insect Vectors | pt_BR |
| Título | A deep insight into the sialome of Rhodnius neglectus, a vector of Chagas disease | pt_BR |
| Tipo del documento | Article | pt_BR |
| DOI | 10.1371/journal.pntd.0004581 | |
| Resumen en Inglés | Background: Triatomines are hematophagous insects that act as vectors of Chagas disease. Rhodnius neglectus is one of these kissing bugs found, contributing to the transmission of this American trypanosomiasis. The saliva of hematophagous arthropods contains bioactive molecules responsible for counteracting host haemostatic, inflammatory, and immune responses. Methods/Principal Findings: Next generation sequencing and mass spectrometry-based protein identification were performed to investigate the content of triatomine R. neglectus saliva. We deposited 4,230 coding DNA sequences (CDS) in GenBank. A set of 636 CDS of proteins of putative secretory nature was extracted from the assembled reads, 73 of them confirmed by proteomic analysis. The sialome of R. neglectus was characterized and serine protease transcripts detected. The presence of ubiquitous protein families was revealed, including lipocalins, serine protease inhibitors, and antigen-5. Metalloproteases, disintegrins, and odorant binding protein families were less abundant. Conclusions/Significance: The data presented improve our understanding of hematophagous arthropod sialomes, and aid in understanding hematophagy and the complex interplay among vectors and their vertebrate hosts. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil / National Institute of Allergy and Infectious Disease. Laboratory of Malaria and Vector Research. Vector Biology Section. Rockville, MA, United States of America. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil / University of Brasília. Ceilândia Faculty. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Goiás. Department of Parasitology. Jataí, GO, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil / Fundação Oswaldo Cruz. Fiocruz Amazônas - Instituto Leônidas e Maria Deane. Manaus, AM, Brasil. | pt_BR |
| Afiliación | University of Brasília. Department of Computer Science. Brasília, DF, Brazil. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Afiliación | National Institute of Allergy and Infectious Disease. Laboratory of Malaria and Vector Research. Vector Biology Section. Rockville, MA, United States of America. | pt_BR |
| Afiliación | National Institute of Allergy and Infectious Disease. Laboratory of Malaria and Vector Research. Vector Biology Section. Rockville, MA, United States of America. | pt_BR |
| Afiliación | University of Brasília. Department of Cell Biology. Brasília, DF, Brazil. | pt_BR |
| Palavras clave en Inglês | Rhodnius neglectus | pt_BR |
| Palavras clave en Inglês | Chagas disease | pt_BR |
| Palavras clave en Inglês | Insect Vectors | pt_BR |
| Palavras clave en Inglês | American trypanosomiasis | pt_BR |
| DeCS | Doença de Chagas | pt_BR |
| DeCS | Espectrometria de Massas | pt_BR |
| DeCS | Dados de Sequência Molecular | pt_BR |
| DeCS | Peptídeo Hidrolases | pt_BR |
| DeCS | Proteínas e Peptídeos Salivares | pt_BR |
| DeCS | Insetos Vetores | pt_BR |
| DeCS | Rhodnius | pt_BR |
| DeCS | Análise de Sequência de DNA | pt_BR |
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