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MOLECULAR EVIDENCE THAT HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 DISSEMINATION IN A SMALL BRAZILIAN CITY WAS ALREADY TAKING PLACE IN THE EARLY 1990S
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Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil / Universidade Federal do Estado do Rio de Janeiro. Hospital Universitário Gaffrée e Guinle. Rio de Janeiro, RJ, Brasil / Programa Municipal de HIV/Aids de Miracema, Miracema, RJ, Brasil.
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil;
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil;
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil;
Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Aids & Imunologia Molecular. Rio de Janeiro, RJ, Brasil;
Abstract
We recently performed a molecular epidemiology survey of human immunodeficiency virus type 1 (HIV-1) infection in Miracema, a small city in Southeast Brazil, and found multiple monophyletic clusters, consistent with independent introductions and spread of different viral lineages in the city. Here we apply Bayesian coalescent-based methods to the two largest subtype B clusters and estimate that the most recent common ancestors that gave rise to these two transmission chains were in circulation around 1991-1992. The finding that HIV-1 spread in this Brazilian small city was already taking place at a time Aids was considered a problem restricted to large urban centers may have important public health implications.
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