| Author | Xavier, Gabriel Silva | |
| Author | Teles, Amanda Mara | |
| Author | Moragas-Tellis, Carla Junqueira | |
| Author | Chagas, Maria do Socorro dos Santos | |
| Author | Behrens, Maria Dutra | |
| Author | Moreira, Wendel Fragoso de Freitas | |
| Author | Silva, Ana Lucia Abreu | |
| Author | Calabrese, Kátia da Silva | |
| Author | Nascimento, Maria do Desterro Soares Brandão | |
| Author | Souza, Fernando Almeida | |
| Access date | 2021-06-25T20:48:58Z | |
| Available date | 2021-06-25T20:48:58Z | |
| Document date | 2021 | |
| Citation | XAVIER, Gabriel Silva et al. Inhibitory Effect of Catechin-Rich Açaí Seed Extract on LPS-Stimulated RAW 264.7 Cells and Carrageenan-Induced Paw Edema. Foods, v.10. n. 1014, 14 p, May 2021. | pt_BR |
| ISSN | 2304-8158 | pt_BR |
| URI | https://www.arca.fiocruz.br/handle/icict/47879 | |
| Language | eng | pt_BR |
| Publisher | MDPI | pt_BR |
| Rights | open access | |
| Subject in Portuguese | Inflamação | pt_BR |
| Subject in Portuguese | Euterpe oleracea | pt_BR |
| Subject in Portuguese | Fruta | pt_BR |
| Subject in Portuguese | Óxido Nítrico | pt_BR |
| Subject in Portuguese | Citocinas | pt_BR |
| Subject in Portuguese | Histologia | pt_BR |
| Subject in Portuguese | Mastócitos | pt_BR |
| Title | Inhibitory Effect of Catechin-Rich Açaí Seed Extract on LPS-Stimulated RAW 264.7 Cells and Carrageenan-Induced Paw Edema | pt_BR |
| Type | Article | |
| DOI | 10.3390/foods10051014 | |
| Abstract | Açaí berry is a fruit from the tree commonly known as açaízeiro (Euterpe oleracea Mart.) originated from the Amazonian region and widely consumed in Brazil. There are several reports of the anti-inflammatory activity of its pulp and few data about the seed’s potential in inflammation control. This work aimed to evaluate the effect of catechin-rich açaí extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 cells and carrageenan-induced paw edema. The treatment with E. oleracea ethyl acetate extract (EO-ACET) was used in an in vitro model performed with macrophages stimulated by LPS, in which pro-inflammatory markers were evaluated, and in an in vivo model of acute inflammation, in which edema inhibition was evaluated. EO-ACET showed an absence of endotoxins, and did not display cytotoxic effects in RAW 264.7 cells. LPS-stimulated cells treated with EO-ACET displayed low levels of nitrite and interleukins (IL’s), IL-1β, IL-6 and IL-12, when compared to untreated cells. EO-ACET treatment was able to inhibit carrageenan-induced paw edema at 500 and 1000 mg/kg, in which no acute inflammatory reaction or low mast cell counts were observed by histology at the site of inoculation of λ-carrageenan. These findings provide more evidence to support further studies with E. oleracea seeds for the treatment of inflammation. | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Rede Nordeste de Biotecnologia. São Luis, MA, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Pós-Graduação em Saúde do Adulto. São Luis, MA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos—Farmanguinhos. Laboratório de Produtos Naturais para Saúde Pública. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos—Farmanguinhos. Laboratório de Produtos Naturais para Saúde Pública. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto de Tecnologia em Fármacos—Farmanguinhos. Laboratório de Produtos Naturais para Saúde Pública. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Pós-graduação em Ciência Animal. São Luis, MA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Pós-graduação em Ciência Animal. São Luis, MA, Brasil. | pt_BR |
| Affilliation | Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Affilliation | Universidade Federal do Maranhão. Rede Nordeste de Biotecnologia. São Luis, MA, Brasil. | pt_BR |
| Affilliation | Universidade Estadual do Maranhão. Pós-graduação em Ciência Animal. São Luis, MA, Brasil / Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Imunomodulação e Protozoologia. Rio de Janeiro, RJ, Brasil. | pt_BR |
| Subject | Inflammation | pt_BR |
| Subject | Euterpe oleracea | pt_BR |
| Subject | Fruit | pt_BR |
| Subject | Nitric oxide | pt_BR |
| Subject | Cytokines | pt_BR |
| Subject | Histology | pt_BR |
| Subject | Mast cells | pt_BR |
